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Current Techniques for MR Imaging of Atherosclerosis

Current Techniques for MR Imaging of Atherosclerosis ORIGINAL ARTICLE Niranjan Balu, PhD,* Jinnan Wang, PhD,Þ Li Dong, MD,* Florence Baluyot, MS,þ Huijun Chen, PhD,* and Chun Yuan, PhD* tion, neovasculature, and inflammation have been implicated as Abstract: Vessel wall imaging of large vessels has the potential factors related to plaque vulnerability. Thus, imaging modalities to identify culprit atherosclerotic plaques that lead to cardiovas- with the ability to interrogate the vessel wall to detect and quan- cular events. Comprehensive assessment of atherosclerotic plaque tify all biomarkers of atherosclerotic plaques offer the best pro- spects of identifying vulnerable plaques. size, composition, and biological activity is possible with mag- Imaging biomarkers of atherosclerosis can be classified netic resonance imaging (MRI). Magnetic resonance imaging of into morphological, plaque compositional, and plaque activity the atherosclerotic plaque has demonstrated high accuracy and indices (Table 1). Plaque morphology indices include plaque size measurement reproducibility for plaque size. The accuracy of in measurements such as volume, thickness, and area. Plaque com- vivo multicontrast MRI for identification of plaque composition positional measurements pertain to quantitative measures of lipid has been validated against histological findings. Magnetic reso- core, fibrous cap, hemorrhage, thrombus, and loose matrix com- nance imaging markers of plaque biological activity such as ponents. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Topics in Magnetic Resonance Imaging Wolters Kluwer Health

Current Techniques for MR Imaging of Atherosclerosis

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ISSN
0899-3459
eISSN
1536-1004
DOI
10.1097/RMR.0b013e3181ea287d
pmid
20805731
Publisher site
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Abstract

ORIGINAL ARTICLE Niranjan Balu, PhD,* Jinnan Wang, PhD,Þ Li Dong, MD,* Florence Baluyot, MS,þ Huijun Chen, PhD,* and Chun Yuan, PhD* tion, neovasculature, and inflammation have been implicated as Abstract: Vessel wall imaging of large vessels has the potential factors related to plaque vulnerability. Thus, imaging modalities to identify culprit atherosclerotic plaques that lead to cardiovas- with the ability to interrogate the vessel wall to detect and quan- cular events. Comprehensive assessment of atherosclerotic plaque tify all biomarkers of atherosclerotic plaques offer the best pro- spects of identifying vulnerable plaques. size, composition, and biological activity is possible with mag- Imaging biomarkers of atherosclerosis can be classified netic resonance imaging (MRI). Magnetic resonance imaging of into morphological, plaque compositional, and plaque activity the atherosclerotic plaque has demonstrated high accuracy and indices (Table 1). Plaque morphology indices include plaque size measurement reproducibility for plaque size. The accuracy of in measurements such as volume, thickness, and area. Plaque com- vivo multicontrast MRI for identification of plaque composition positional measurements pertain to quantitative measures of lipid has been validated against histological findings. Magnetic reso- core, fibrous cap, hemorrhage, thrombus, and loose matrix com- nance imaging markers of plaque biological activity such as ponents.

Journal

Topics in Magnetic Resonance Imaging – Wolters Kluwer Health

Published: Aug 1, 2009

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