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W. Szpirt, J. Heaf, J. Petersen (2011)
Plasma exchange for induction and cyclosporine A for maintenance of remission in Wegener's granulomatosis--a clinical randomized controlled trial.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 26 1
Hong Xiao, P. Heeringa, P. Hu, Zhi Liu, Minglang Zhao, Y. Aratani, N. Maeda, R. Falk, J. Jennette (2002)
Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice.The Journal of clinical investigation, 110 7
J. Damoiseaux, E. Csernok, N. Rasmussen, F. Moosig, P. Paassen, B. Baslund, P. Vermeersch, D. Blockmans, J. Tervaert, X. Bossuyt (2016)
Detection of antineutrophil cytoplasmic antibodies (ANCAs): a multicentre European Vasculitis Study Group (EUVAS) evaluation of the value of indirect immunofluorescence (IIF) versus antigen-specific immunoassaysAnnals of the Rheumatic Diseases, 76
G. Dekkema, T. Bijma, P. Jellema, A. Berg, B. Kroesen, C. Stegeman, P. Heeringa, W. Abdulahad, J. Sanders (2019)
Increased miR-142-3p Expression Might Explain Reduced Regulatory T Cell Function in Granulomatosis With PolyangiitisFrontiers in Immunology, 10
P. Grayson, M. Kaplan (2016)
At the Bench: Neutrophil extracellular traps (NETs) highlight novel aspects of innate immune system involvement in autoimmune diseasesJournal of Leukocyte Biology, 99
M. Boomsma (2001)
Anca associated vasculitis: occurrence, prediction, prevention, and outcome of relapses
Bossuyt (2017)
1633Rheumatology (Oxford), 56
N. Rasmussen, J. Damoiseaux, E. Csernok, N. Heegaard, B. Hellmich, P. Paassen, B. Baslund, P. Vermeersch, D. Blockmans, J. Tervaert, X. Bossuyt (2017)
Individual values of antineutrophil cytoplasmic antibodies do not correspond between antigen-specific assaysClinical Chemistry and Laboratory Medicine (CCLM), 56
E. Csernok, J. Damoiseaux, N. Rasmussen, B. Hellmich, P. Paassen, P. Vermeersch, D. Blockmans, J. Tervaert, X. Bossuyt (2016)
Evaluation of automated multi-parametric indirect immunofluorescence assays to detect anti-neutrophil cytoplasmic antibodies (ANCA) in granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA).Autoimmunity reviews, 15 7
K. Samman, C. Ross, C. Pagnoux, Jean-Paul Makhzoum (2021)
Update in the Management of ANCA-Associated Vasculitis: Recent Developments and Future PerspectivesInternational Journal of Rheumatology, 2021
M. Laudien, S. Gadola, R. Podschun, J. Hedderich, J. Paulsen, E. Reinhold-Keller, E. Csernok, P. Ambrosch, B. Hellmich, F. Moosig, W. Gross, H. Sahly, P. Lamprecht (2010)
Nasal carriage of Staphylococcus aureus and endonasal activity in Wegener s granulomatosis as compared to rheumatoid arthritis and chronic Rhinosinusitis with nasal polyps.Clinical and experimental rheumatology, 28 1 Suppl 57
Evdokia Sfiniadaki, I. Tsiara, P. Theodossiadis, I. Chatziralli (2019)
Ocular Manifestations of Granulomatosis with Polyangiitis: A Review of the LiteratureOphthalmology and Therapy, 8
C. Kallenberg, C. Stegeman, W. Abdulahad, P. Heeringa (2013)
Pathogenesis of ANCA-associated vasculitis: new possibilities for intervention.American journal of kidney diseases : the official journal of the National Kidney Foundation, 62 6
Lucy McGeoch, M. Twilt, Leilani Famorca, V. Bakowsky, Lillian Barra, S. Benseler, D. Cabral, S. Carette, G. Cox, N. Dhindsa, Christine Dipchand, A. Fifi-Mah, M. Goulet, N. Khalidi, M. Khraishi, P. Liang, N. Milman, C. Pineau, H. Reich, Nooshin Samadi, K. Shojania, R. Taylor-Gjevre, T. Towheed, J. Trudeau, M. Walsh, E. Yacyshyn, C. Pagnoux (2016)
CanVasc Recommendations for the Management of Antineutrophil Cytoplasm Antibody-associated VasculitidesThe Journal of Rheumatology, 43
P. Fraticelli, D. Benfaremo, A. Gabrielli (2021)
Diagnosis and management of leukocytoclastic vasculitisInternal and Emergency Medicine, 16
(2000)
Prediction of relapses in Wegener's granulomatosis by measurement of antineutrophil cytoplasmic antibody levels: a prospective study, 43
L. Mandl, D. Solomon, E. Smith, R. Lew, J. Katz, R. Shmerling (2002)
Using antineutrophil cytoplasmic antibody testing to diagnose vasculitis: can test-ordering guidelines improve diagnostic accuracy?Archives of internal medicine, 162 13
A. Mueller, K. Holl-Ulrich, W. Gross (2013)
Granuloma in ANCA-Associated Vasculitides: Another Reason to Distinguish Between Syndromes?Current Rheumatology Reports, 15
This review provides an up to date summary of recent trials and suggests treatment guidelines for induction and maintenance of remission based on the latest recommendations
Nazanin Ebrahimiadib, B. Modjtahedi, Ramak Roohipoor, S. Anesi, C. Foster (2016)
Successful Treatment Strategies in Granulomatosis With Polyangiitis-Associated Peripheral Ulcerative KeratitisCornea, 35
Joanna (Wojciechowska), K. Kościelska-Kasprzak, W. Krajewski, Krzysztof Morawski (2019)
Serum levels of interleukin-32 and interleukin-6 in granulomatosis with polyangiitis and microscopic polyangiitis: association with clinical and biochemical findingsEuropean Cytokine Network, 30
F. Woude, S. Lobatto, H. Permin, M. Giessen, N. Rasmussen, A. Wiik, L. Es, G. Hem, T. The (1985)
AUTOANTIBODIES AGAINST NEUTROPHILS AND MONOCYTES: TOOL FOR DIAGNOSIS AND MARKER OF DISEASE ACTIVITY IN WEGENER'S GRANULOMATOSISThe Lancet, 325
Cynthia Bullen, T. Liesegang, T. Mcdonald, R. Deremee (1983)
Ocular complications of Wegener's granulomatosis.Ophthalmology, 90 3
D. Spalton, E. Graham, N. Page, M. Sanders (1981)
Ocular changes in limited forms of Wegener's granulomatosis.British Journal of Ophthalmology, 65
Boomsma (2000)
2025Arthritis Rheum, 43
Laudien (2010)
51Clin Exp Rheumatol, 28
(1985)
This latest article describes the updates in the classification criteria after discussion with the international experts on granulomatosis polyangiitis. 3. van der Woude FJ
Guy Hoffman, G. Kerr, R. Leavitt, C. Hallahan, R. Lebovics, W. Travis, M. Rottem, A. Fauci (1992)
Wegener Granulomatosis: An Analysis of 158 PatientsAnnals of Internal Medicine, 116
S. Cassan, M. Divertie, R. Hollenhorst, E. Harrison (1970)
Pseudotumor of the orbit and limited Wegener's granulomatosis.Annals of internal medicine, 72 5
Choi (2001)
1584J Rheumatol, 28
L. Gonzalez-Gonzalez, Nicolás Molina-Prat, P. Doctor, J. Tauber, M. Maza, C. Foster (2014)
Clinical Features and Presentation of Posterior Scleritis: A Report of 31 CasesOcular Immunology and Inflammation, 22
Li (2018)
413Exp Ther Med, 16
J. Savige, D. Gillis, E. Benson, D. Davies, V. Esnault, R. Falk, E. Hagen, D. Jayne, J. Jennette, B. Paspaliaris, W. Pollock, C. Pusey, C. Savage, R. Silvestrini, F. Woude, J. Wieslander, A. Wiik (1999)
International Consensus Statement on Testing and Reporting of Antineutrophil Cytoplasmic Antibodies (ANCA)American journal of clinical pathology, 111 4
A. Schreiber, A. Rousselle, J. Becker, A. Mässenhausen, A. Linkermann, R. Kettritz (2017)
Necroptosis controls NET generation and mediates complement activation, endothelial damage, and autoimmune vasculitisProceedings of the National Academy of Sciences, 114
Jenny Fäldt, Claes Dahlgren, Anna Karlsson, A. Ahmed, D. Minnikin, Malin Ridell (1999)
Activation of human neutrophils by mycobacterial phenolic glycolipidsClinical & Experimental Immunology, 118
(2017)
Position paper: Revised 2017 international consensus on testing of ANCAs in granulomatosis with polyangiitis and microscopic polyangiitis, 13
S. Mehta, N. Chitnis, Amey Medhekar (2022)
Utility of Optical Coherence Tomography Angiography (OCTA) in Granulomatosis With PolyangiitisCureus, 14
Z. Wallace, E. Miloslavsky (2020)
Management of ANCA associated vasculitisBMJ, 368
X. Bossuyt, J. Tervaert, Y. Arimura, D. Blockmans, L. Flores-Suárez, L. Guillevin, B. Hellmich, D. Jayne, J. Jennette, C. Kallenberg, S. Moiseev, P. Novikov, A. Radice, J. Savige, R. Sinico, U. Specks, P. Paassen, Ming‐hui Zhao, N. Rasmussen, J. Damoiseaux, E. Csernok (2017)
Revised 2017 international consensus on testing of ANCAs in granulomatosis with polyangiitis and microscopic polyangiitisNature Reviews Rheumatology, 13
C. Stegeman, J. Tervaert, W. Sluiter, W. Manson, P. Jong, C. Kallenberg (1994)
Association of Chronic Nasal Carriage of Staphylococcus aureus and Higher Relapse Rates in Wegener GranulomatosisAnnals of Internal Medicine, 120
P. Majumder, S. Sudharshan, A. George, S. Ganesh, J. Biswas (2018)
Antineutrophil cytoplasmic antibody-positive scleritis: Clinical profile of patients from a tuberculosis-endemic regionIndian Journal of Ophthalmology, 66
Jiakai Li, Chuang-hua Li, Jiaojiao Li (2018)
Thoracic manifestation of Wegener's granulomatosis: Computed tomography findings and analysis of misdiagnosis.Experimental and therapeutic medicine, 16 1
Robson (2022)
315Ann Rheum Dis, 81
R. Falk, R. Terrell, L. Charles, J. Jennette (1990)
Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro.Proceedings of the National Academy of Sciences of the United States of America, 87
Hyon Choi, Simin Liu, P. Merkel, G. Colditz, J. Niles (2001)
Diagnostic performance of antineutrophil cytoplasmic antibody tests for idiopathic vasculitides: metaanalysis with a focus on antimyeloperoxidase antibodies.The Journal of rheumatology, 28 7
P. Grayson, C. Ponte, R. Suppiah, J. Robson, A. Craven, A. Judge, S. Khalid, A. Hutchings, R. Luqmani, R. Watts, P. Merkel (2022)
2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Eosinophilic Granulomatosis with PolyangiitisAnnals of the Rheumatic Diseases, 81
A. Tarabishy, M. Schulte, G. Papaliodis, G. Hoffman (2010)
Wegener's granulomatosis: clinical manifestations, differential diagnosis, and management of ocular and systemic disease.Survey of ophthalmology, 55 5
L. Barbera, F. Macaluso, S. Fasano, G. Grasso, F. Ciccia, G. Guggino (2022)
Microbiome Changes in Connective Tissue Diseases and Vasculitis: Focus on Metabolism and InflammationInternational Journal of Molecular Sciences, 23
Y. Nozaki (2021)
New Insights Into Novel Therapeutic Targets in ANCA-Associated VasculitisFrontiers in Immunology, 12
P. Kuchynka (1982)
[Ocular manifestations of wegener's granulomatosis].Ophthalmologica, 185
Xiao (2002)
955J Clin Invest, 110
M. Yates, R. Watts, I. Bajema, M. Cid, B. Crestani, T. Hauser, B. Hellmich, J. Holle, M. Laudien, M. Little, R. Luqmani, A. Mahr, P. Merkel, J. Mills, J. Mooney, M. Segelmark, V. Tesar, K. Westman, A. Vaglio, N. Yalçındağ, D. Jayne, C. Mukhtyar (2016)
EULAR/ERA-EDTA recommendations for the management of ANCA-associated vasculitisAnnals of the Rheumatic Diseases, 75
J. Jennette, Ronald Falk, P. Hu, Hong Xiao (2013)
Pathogenesis of antineutrophil cytoplasmic autoantibody-associated small-vessel vasculitis.Annual review of pathology, 8
J. Tervaert, F. Woude, A. Fauci, J. Ambrus, J. Velosa, W. Keane, S. Meijer, M. Giessen, G. Hem, C. Kallenberg (1989)
Association between active Wegener's granulomatosis and anticytoplasmic antibodies.Archives of internal medicine, 149 11
Krajewska Wojciechowska (2019)
151Eur Cytokine Netw, 30
X. Bossuyt, N. Rasmussen, P. Paassen, B. Hellmich, B. Baslund, P. Vermeersch, D. Blockmans, J. Tervaert, E. Csernok, J. Damoiseaux (2017)
A multicentre study to improve clinical interpretation of proteinase-3 and myeloperoxidase anti-neutrophil cytoplasmic antibodiesRheumatology, 56
M. Harigai, M. Tsutsumino, H. Takada, K. Nagasaka (2019)
Molecular targeted therapies for microscopic polyangiitis and granulomatosis with polyangiitisThe Korean Journal of Internal Medicine, 34
A. Tullo, P. Durrington, E. Graham, L. Holt, D. Easty, R. Bonshek, Joan Noble (1995)
Florid xanthelasmata (yellow lids) in orbital Wegener's granulomatosis.British Journal of Ophthalmology, 79
J. Sanders, M. Huitma, C. Kallenberg, C. Stegeman (2006)
Prediction of relapses in PR3-ANCA-associated vasculitis by assessing responses of ANCA titres to treatment.Rheumatology, 45 6
In this review the pathogenesis, clinical approach, and evidence-based treatment options for the management of ANCA associated vasculitis patients has been discussed
J. Robson, P. Grayson, C. Ponte, R. Suppiah, A. Craven, A. Judge, S. Khalid, A. Hutchings, R. Watts, P. Merkel, R. Luqmani (2022)
2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for granulomatosis with polyangiitisAnnals of the Rheumatic Diseases, 81
R. Ghanem, N. Chang, L. Aoki, R. Santo, S. Matayoshi (2004)
Vasculitis of the lacrimal sac wall in Wegener granulomatosis.Ophthalmic plastic and reconstructive surgery, 20 3
Brian D’Anza, C. Langford, R. Sindwani (2017)
Sinonasal Imaging Findings in Granulomatosis with Polyangiitis (Wegener Granulomatosis): A Systematic ReviewAmerican Journal of Rhinology & Allergy, 31
Lei Shi (2017)
Anti-neutrophil cytoplasmic antibody-associated vasculitis: prevalence, treatment, and outcomesRheumatology International, 37
Mark McClure, S. Gopaluni, D. Jayne, Rachel Jones (2018)
B cell therapy in ANCA-associated vasculitis: current and emerging treatment optionsNature Reviews Rheumatology, 14
B. Straatsma (1957)
Ocular manifestations of Wegener's granulomatosis.American journal of ophthalmology, 44 6
B. Haynes, M. Fishman, A. Fauci, S. Wolff (1977)
The ocular manifestations of Wegener's granulomatosis. Fifteen years experience and review of the literature.The American journal of medicine, 63 1
Arnold Lee (2021)
Avacopan: First ApprovalDrugs, 82
Daigo Nakazawa, S. Masuda, U. Tomaru, A. Ishizu (2018)
Pathogenesis and therapeutic interventions for ANCA-associated vasculitisNature Reviews Rheumatology, 15
M. Hello, S. Barbarot, A. Masseau, E. Cassagnau, M. Hamidou (2010)
[Xanthelasma associated with Wegener's granulomatosis].Annales de dermatologie et de venereologie, 137 2
S. Macarie, Răzvan-Marian Mihăilă, D. Macarie, Dan-Alexandru Toc (2021)
Therapy of ocular complications in ANCA+ associated vasculitisRomanian Journal of Ophthalmology, 65
J. Cordier, D. Valeyre, L. Guillevin, R. Loire, J. Bréchot (1990)
Pulmonary Wegener's granulomatosis. A clinical and imaging study of 77 cases.Chest, 97 4
M. Hibino, T. Kondo (2017)
Dacryoadenitis with Ptosis and Diplopia as the Initial Presentation of Granulomatosis with PolyangiitisInternal Medicine, 56
Muller Kobold, T. Roelie, van Wijk, C. Franssen, G. Molema, M. CeesG., Kallenberg, J. Willem, C. Tervaert (1999)
In vitro up-regulation of E-selectin and induction of interleukin-6 in endothelial cells by autoantibodies in Wegener's granulomatosis and microscopic polyangiitis.Clinical and experimental rheumatology, 17 4
Mehta (2022)
e22612Cureus, 14
A. Müller, B. Krause, Anja Kerstein-Stähle, Sara Comdühr, S. Klapa, S. Ullrich, K. Holl-Ulrich, P. Lamprecht (2021)
Granulomatous Inflammation in ANCA-Associated VasculitisInternational Journal of Molecular Sciences, 22
K. Kessenbrock, M. Krumbholz, U. Schönermarck, W. Back, W. Gross, Z. Werb, H. Gröne, V. Brinkmann, D. Jenne (2009)
Netting neutrophils in autoimmune small-vessel vasculitisNature Medicine, 15
A. Kerstein, S. Schüler, O. Cabral-Marques, J. Fazio, R. Häsler, A. Müller, S. Pitann, F. Moosig, S. Klapa, C. Haas, D. Kabelitz, G. Riemekasten, S. Wolters, P. Lamprecht (2017)
Environmental factor and inflammation-driven alteration of the total peripheral T-cell compartment in granulomatosis with polyangiitis.Journal of autoimmunity, 78
Muller Kobold (1999)
433Clin Exp Rheumatol, 17
D. Geetha, J. Jefferson (2020)
ANCA-Associated Vasculitis: Core Curriculum 2020.American journal of kidney diseases : the official journal of the National Kidney Foundation
Purpose of reviewGranulomatosis with polyangiitis (GPA), a multisystem disease with diverse systemic and protean ocular manifestations. Its pathophysiology, spectrum of the ocular manifestations, changing paradigms in the diagnosis of the disease, recent updates in the treatment patterns are clinically relevant to the treating clinician. They are described in this review.Recent findings1.The ocular manifestations are not included in the updated diagnostic criteria of GPA. Hence, high index of suspicion is required when a clinician encounters eye as the first clinical presentation.2.The concentration of interleukin -32 and 6 are correlated to disease activity of GPA.3.Enzyme-linked immunoassay for antineutophilic antibodies are recommended over indirect immunofluorescence to detect the subtypes with clinical correlation. The false positivity of test results in tuberculosis needs to be ruled out.4.Both rituximab and cyclophosphamide are equally considered as a first line of therapy of GPA in the induction phase as per randomized studies. During the continuation phase, switch over to methotrexate and mycophenolate can be considered.SummaryThe changing trends in the diagnosis, treatment can be adapted to real time clinical practice to provide the best quality of life to patients with GPA.
Current Opinion in Ophthalmology – Wolters Kluwer Health
Published: Nov 21, 2022
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