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Circulation: Cardiovascular Imaging EDITORIAL Correlation of F-NaF Activity With Progression of Macrocalcification Another Step Toward Vulnerable Plaque Detection? See Article by Doris et al Panithaya Chareonthaitawee , MD ver the past few decades, multiple observational studies have confirmed Fabien Hyafil , MD, PhD that most plaques causing myocardial infarction have certain key histo- Opathologic features including but not limited to the presence of a large necrotic core, a thin fibrous cap, a positively remodeled vessel, macrophage infil- tration, neovascularization, and microcalcification. These high-risk pathophysi- ological features may even be present before a clinical plaque rupture event, im- plying utility in the prospective identification of high-risk plaques. This long search for a prophetic tool has included numerous invasive and noninvasive imaging modalities, with generally excellent negative predictive value for excluding high- risk plaques but relatively low positive predictive values perhaps because these modalities recognize only one or more high-risk plaque characteristics, thus limit- 2,3 ing their clinical utility. Molecular imaging offers a unique approach to high-risk plaque detection in its ability to measure biologic activity. In particular, F-NaF has emerged as a promising positron emission tomography (PET) radiotracer for identifying the high-risk coro- 4 18 nary plaque. Long considered a
Circulation: Cardiovascular Imaging – Wolters Kluwer Health
Published: Dec 1, 2020
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