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Editorial Are They Ready for Use? Paolo Raggi, MD; Nikolaos Alexopoulos, MD oronary computed tomography angiography (CCTA) is above the 50th and 75th SIS percentile (SIS%) compared Cfrequently used in symptomatic patients to exclude the with those below the 50th percentile. While death and major presence of obstructive coronary artery disease. Beyond high adverse cardiovascular events were predicted by SIS% in the diagnostic accuracy, it provides valuable prognostic infor- derivation cohort, only major adverse cardiovascular events mation. There is accumulating evidence that a patient’s risk were predicted by SIS% in the validation cohort. Women of major adverse events is not solely due to the presence of demonstrated a higher hazard of events than men when their obstructive coronary artery disease but also to the presence SIS was above the 75th percentile both in the derivation and of nonobstructive atherosclerotic disease. In this light, CCTA the validation cohort. Naturally, the event rate increased with has a definite advantage over invasive angiography because increasing age and SIS%. The effort made by the investigators it provides information on plaque volume and composition resembles closely the quantification of coronary atherosclero- beyond luminal stenosis. Currently, CCTA is the only nonin- sis on noncontrast computed
Circulation: Cardiovascular Imaging – Wolters Kluwer Health
Published: Mar 1, 2017
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