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Corneal angiogenesis and lymphangiogenesis

Corneal angiogenesis and lymphangiogenesis REVIEW URRENT PINION Birgit Regenfuß, Felix Bock, and Claus Cursiefen Purpose of review The purpose of the present review is to describe new antilymphangiogenic treatment strategies and recent findings on strain-dependency of corneal lymphangiogenesis and the interdependency between blood and lymphatic vessel growth. Recent findings Studies on mice have revealed that apart from haemangiogenesis, lymphangiogenesis can also differ markedly between several mouse strains under normal and inflammatory conditions. Although haemangiogenesis and lymphangiogenesis are closely interconnected in their spatial-temporal patterning, recent data suggest that they can also occur independently. Summary Understanding the coordinated regulation of blood and lymphatic vessel growth and genetic factors determining lymphangiogenesis in more detail could improve the development of specifically targeted antihaemangiogenic or antilymphangiogenic strategies. Keywords angiogenesis, corneal lymphangiogenesis, genetic heterogeneity, inhibitors of lymphangiogenesis INTRODUCTION administration of VEGF-A leads to a reduced num- ber of filopodia and less migration [3]. VEGF-A Angiogenesis is commonly defined as the process signals are transmitted via vascular endothelial of new capillary blood vessel growth from the growth factor receptor 2 (VEGFR2), which is punc- preexisting vasculature. tually expressed in the filopodia of the endothelial The established classical mechanisms of new tip cells. Stalk cells proliferate and establish the vessel growth http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Allergy and Clinical Immunology Wolters Kluwer Health

Corneal angiogenesis and lymphangiogenesis

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Copyright © Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited.
ISSN
1528-4050
eISSN
1473-6322
DOI
10.1097/ACI.0b013e328357b4a2
pmid
22951910
Publisher site
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Abstract

REVIEW URRENT PINION Birgit Regenfuß, Felix Bock, and Claus Cursiefen Purpose of review The purpose of the present review is to describe new antilymphangiogenic treatment strategies and recent findings on strain-dependency of corneal lymphangiogenesis and the interdependency between blood and lymphatic vessel growth. Recent findings Studies on mice have revealed that apart from haemangiogenesis, lymphangiogenesis can also differ markedly between several mouse strains under normal and inflammatory conditions. Although haemangiogenesis and lymphangiogenesis are closely interconnected in their spatial-temporal patterning, recent data suggest that they can also occur independently. Summary Understanding the coordinated regulation of blood and lymphatic vessel growth and genetic factors determining lymphangiogenesis in more detail could improve the development of specifically targeted antihaemangiogenic or antilymphangiogenic strategies. Keywords angiogenesis, corneal lymphangiogenesis, genetic heterogeneity, inhibitors of lymphangiogenesis INTRODUCTION administration of VEGF-A leads to a reduced num- ber of filopodia and less migration [3]. VEGF-A Angiogenesis is commonly defined as the process signals are transmitted via vascular endothelial of new capillary blood vessel growth from the growth factor receptor 2 (VEGFR2), which is punc- preexisting vasculature. tually expressed in the filopodia of the endothelial The established classical mechanisms of new tip cells. Stalk cells proliferate and establish the vessel growth

Journal

Current Opinion in Allergy and Clinical Immunology – Wolters Kluwer Health

Published: Oct 1, 2012

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