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Considerations in the development of nonhuman primate models of combination antiretroviral therapy for studies of AIDS virus suppression, residual virus, and curative strategies

Considerations in the development of nonhuman primate models of combination antiretroviral... REVIEW URRENT Considerations in the development of nonhuman PINION primate models of combination antiretroviral therapy for studies of AIDS virus suppression, residual virus, and curative strategies Gregory Q. Del Prete and Jeffrey D. Lifson Purpose of review Animal models will be critical for preclinical evaluations of novel HIV eradication and/or functional cure strategies in the setting of suppressive combination antiretroviral therapy (cART). Here, the strengths, limitations, and challenges of recent efforts to develop nonhuman primate (NHP) models of cART-mediated suppression for use in studies of persistent virus and curative approaches are discussed. Recent findings Several combinations of NHP species and viruses that recapitulate key aspects of human HIV infection have been adapted for cART-mediated suppression studies. Different cART regimens incorporating drugs targeting multiple different steps of the viral replication cycle have provided varying levels of virologic suppression, dependent in part upon the host species, virus, drug regimen and timing, and virologic monitoring assay sensitivity. New, increasingly sensitive virologic monitoring approaches for measurements of plasma viral RNA, cell-associated and tissue-associated viral RNA and DNA, and the replication- competent residual viral pool in the setting of cART in NHP models are being developed to allow for the assessment of persistent virus http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and Aids Wolters Kluwer Health

Considerations in the development of nonhuman primate models of combination antiretroviral therapy for studies of AIDS virus suppression, residual virus, and curative strategies

Lifson, Jeffrey D.
Current Opinion in HIV and Aids , Volume 8 (4) – Jul 1, 2013
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Copyright
© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
ISSN
1746-630X
eISSN
1746-6318
DOI
10.1097/COH.0b013e328361cf40
pmid
23698559
Publisher site
See Article on Publisher Site

Abstract

REVIEW URRENT Considerations in the development of nonhuman PINION primate models of combination antiretroviral therapy for studies of AIDS virus suppression, residual virus, and curative strategies Gregory Q. Del Prete and Jeffrey D. Lifson Purpose of review Animal models will be critical for preclinical evaluations of novel HIV eradication and/or functional cure strategies in the setting of suppressive combination antiretroviral therapy (cART). Here, the strengths, limitations, and challenges of recent efforts to develop nonhuman primate (NHP) models of cART-mediated suppression for use in studies of persistent virus and curative approaches are discussed. Recent findings Several combinations of NHP species and viruses that recapitulate key aspects of human HIV infection have been adapted for cART-mediated suppression studies. Different cART regimens incorporating drugs targeting multiple different steps of the viral replication cycle have provided varying levels of virologic suppression, dependent in part upon the host species, virus, drug regimen and timing, and virologic monitoring assay sensitivity. New, increasingly sensitive virologic monitoring approaches for measurements of plasma viral RNA, cell-associated and tissue-associated viral RNA and DNA, and the replication- competent residual viral pool in the setting of cART in NHP models are being developed to allow for the assessment of persistent virus

Journal

Current Opinion in HIV and Aids – Wolters Kluwer Health

Published: Jul 1, 2013

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