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Luisa Galati, J. Combes, Purnima Gupta, Rajdip Sen, Alexis Robitaille, Rosario Brancaccio, K. Atsou, C. Cuenin, Sandrine Mckay-Chopin, M. Tornesello, F. Buonaguro, G. Clifford, T. Gheit, M. Tommasino (2020)
Detection of a large spectrum of viral infections in conjunctival premalignant and malignant lesionsInternational Journal of Cancer, 147
P. Moubayed, H. Mwakyoma, D. Schneider (2004)
High frequency of human papillomavirus 6/11, 16, and 18 infections in precancerous lesions and squamous cell carcinoma of the conjunctiva in subtropical Tanzania.American journal of clinical pathology, 122 6
Gichuhi S, Irlam Jh, S. Gichuhi, J. Irlam (2007)
Interventions for squamous cell carcinoma of the conjunctiva in HIV-infected individuals.The Cochrane database of systematic reviews, 2
L. Hämmerl, J. Ferlay, M. Borok, C. Carrilho, D. Parkin (2019)
The burden of squamous cell carcinoma of the conjunctiva in Africa.Cancer epidemiology, 61
(2016)
Conjunctival neoplasms - atlases
Lauren Merz, O. Afriyie, E. Jiagge, E. Adjei, S. Foltin, M. Ludwig, J. Mchugh, J. Brenner, S. Merajver (2019)
Clinical characteristics, HIV status, and molecular biomarkers in squamous cell carcinoma of the conjunctiva in GhanaHealth Science Reports, 2
(2017)
Symposium recent advances and challenges in the management of retinoblastoma globe - saving treatments
HPV16-associated conjunctival cancers appear to be more resistant to treatment than conjunctival cancers not positive for HPVV 16, implications for treatment
C. Carrilho, Chau Miu, Yeji Kim, S. Karki, Alexandra Balmaceda, B. Challa, S. Diamond, Eliane Monteiro, Evelia Marole, C. Lorenzoni, Yolanda Zambujo, Yu-Tseung Liu, R. Schooley, Jonathan Lin (2019)
p16 Expression Correlates with Invasive Ocular Surface Squamous Neoplasms in HIV-Infected MozambicansOcular Oncology and Pathology, 6
Simeon Lauer, J. Malter, J. Meier (1990)
Human papillomavirus type 18 in conjunctival intraepithelial neoplasia.American journal of ophthalmology, 110 1
S. Kaliki, K. Bejjanki, Akruti Desai, Ashik Mohamed (2019)
Interferon Alfa 2b for Ocular Surface Squamous Neoplasia: Factors Influencing the Treatment ResponseSeminars in Ophthalmology, 34
C. Karp, I. Scott, Tom Chang, S. Pflugfelder (1996)
Conjunctival intraepithelial neoplasia : A possible marker for human immunodeficiency virus infection ?Archives of Ophthalmology, 114
T. Dhokotera, J. Bohlius, A. Spoerri, M. Egger, J. Ncayiyana, V. Olago, E. Singh, M. Sengayi (2019)
The burden of cancers associated with HIV in the South African public health sector, 2004–2014: a record linkage studyInfectious Agents and Cancer, 14
(2020)
Conjunctival cancer in people living with HIV, The SAM study
D. Parkin, L. Hämmerl, J. Ferlay, E. Kantelhardt (2020)
Cancer in Africa 2018: The role of infectionsInternational Journal of Cancer, 146
S. Rathi, Anasua Kapoor, S. Kaliki (2018)
Ocular surface squamous neoplasia in HIV-infected patients: current perspectivesHIV/AIDS (Auckland, N.Z.), 10
This study compares the odds of conjunctival cancer in HIV-positive and negative individuals and demonstrates an increasing trend of the odds ratio in the ART era
J. Rossetto, Sandra Molles, C. Gracitelli (2019)
Extensive bulbar conjunctival Kaposi's sarcoma as initial symptom of human immunodeficiency virus.Arquivos brasileiros de oftalmologia
A. Santoni, J. Thariat, C. Maschi, J. Herault, S. Baillif, S. Lassalle, M. Peyrichon, J. Salleron, J. Caujolle (2019)
Management of Invasive Squamous Cell Carcinomas of the Conjunctiva.American journal of ophthalmology, 200
Y. Ruffieux, Mazvita Muchengeti, M. Egger, O. Efthimiou, L. Bartels, V. Olago, M. Davidović, T. Dhokotera, J. Bohlius, Elvira Singh, E. Rohner (2020)
Immunodeficiency and cancer in 3.7 million people living with HIV: the South African HIV Cancer Match Study
H. Griffin, H. Mudhar, P. Rundle, Aslam Shiraz, R. Mahmood, N. Egawa, W. Quint, I. Rennie, J. Doorbar (2019)
Human Papillomavirus type 16 Causes a Defined Subset of Conjunctival In Situ Squamous Cell CarcinomasModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 33
Robert Newton (1996)
A review of the aetiology of squamous cell carcinoma of the conjunctiva.British Journal of Cancer, 74
E. Chokunonga, L. Levy, M. Bassett, M. Borok, B. Mauchaza, Mike Chirenje, D. Parkin (1999)
Aids and cancer in Africa: the evolving epidemic in Zimbabwe.AIDS, 13 18
C. Margo, W. Mack, J. Guffey (1996)
Squamous cell carcinoma of the conjunctiva and human immunodeficiency virus infection.Archives of ophthalmology, 114 3
(2016)
Conjunctival neoplasms-atlases. In: Eyelid, conjunctival and orbital tumours: n atls and textbook
(2016)
National Cancer Registry. Cancer in South Africa
Guech-Ongey (2008)
Elevated risk for squamous cell carcinoma of the conjunctiva among adults with AIDS in the United StatesInt J Cancer, 122
C. Shields, Aparna Ramasubramanian, Phoebe Mellen, J. Shields (2011)
Conjunctival squamous cell carcinoma arising in immunosuppressed patients (organ transplant, human immunodeficiency virus infection).Ophthalmology, 118 11
D. Cruzado-Sanchez, W. Tellez, Beltran Villarreal-Aguilar, Monica Melendez, A. Olivera, Fiorella Moran, Solon Serpas-Frias, Raul Cordero-Garcia (2019)
Conjunctival squamous cell carcinoma: prognostic factors for the recurrence and metastasis and clinicopathological characteristics at an oncological hospital in PeruBritish Journal of Ophthalmology, 104
C. Ateenyi-Agaba (1995)
Conjunctival squamous-cell carcinoma associated with HIV infection in Kampala, UgandaThe Lancet, 345
W. Liggett, D. Sidransky (1998)
Role of the p16 tumor suppressor gene in cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 16 3
P. Kestelyn, A. Stevens, A. Ndayambaje, M. Hanssens, P. Perre (1990)
HIV and conjunctival malignanciesThe Lancet, 336
Lilie Lin, D. Lakomy, E. Chiao, R. Strother, M. Wirth, E. Cesarman, M. Borok, N. Busakhala, C. Chibwesha, L. Chinula, N. Ndlovu, J. Orem, W. Phipps, V. Sewram, Samantha Vogt, J. Sparano, R. Mitsuyasu, S. Krown, S. Gopal (2020)
Clinical Trials for Treatment and Prevention of HIV-Associated Malignancies in Sub-Saharan Africa: Building Capacity and Overcoming BarriersJCO Global Oncology, 6
P. Kestelyn (1990)
Ocular problems in AIDSInternational Ophthalmology, 14
C. Lorenzoni, J. Ferro, C. Carrilho, M. Colombet, D. Parkin (2020)
Cancer in Mozambique: Results from two population‐based cancer registriesInternational Journal of Cancer, 147
C. Donovan, Hershel Patel, Sirikishan Shetty, Lauren Bierman, J. Lustbader, Aruoriwo Oboh-Weilke (2015)
Aggressive conjunctival Kaposi sarcoma as the initial manifestation of acquired immunodeficiency syndromeAmerican Journal of Ophthalmology Case Reports, 19
I. Mirzayev, A. Gündüz, Funda Ateş, Gökçen Özcan, Mehmed Işık (2019)
Factors affecting recurrence after surgical treatment in cases with ocular surface squamous neoplasia.International journal of ophthalmology, 12 9
Ahmad Alfaar, Anas Saad, M. KhalafAllah, O. Elsherif, M. Osman, O. Strauß (2020)
Second primary malignancies of eye and ocular adnexa after a first primary elsewhere in the bodyGraefe's Archive for Clinical and Experimental Ophthalmology, 259
(2016)
Conjunctival cancer in people living with HIV , The SAM study . [ Internet ] . Conference on Retroviruses and Opportunistic Infections . 2020 . 23
Purpose of reviewHistorically, conjunctival cancer has been associated with HIV particularly in sub-Saharan Africa. The human papilloma virus (HPV) has been implicated as a potential causative agent without conclusive evidence. This review covers recent evidence of the epidemiology, diagnosis and treatment of conjunctival cancer in people living with HIV (PLWH).Recent findingsHIV infection has been attributed to 33% of squamous cell carcinoma of the conjunctiva in sub-Saharan Africa. Although clear evidence of the effect of immunodeficiency on conjunctival cancer risk has been demonstrated, the role of HPV on conjunctival cancer development is still unclear. Biomarkers such as the p16 protein are not always indicative of HPV infection. The Epstein–Barr virus (EBV) might potentially be another infectious agent of interest in the development of conjunctival cancer. There is some evidence of increased conjunctival cancer recurrence post treatment as well as increased probability of metastasis in PLWH.SummaryImmunodeficiency increases the risk of conjunctival cancer in PLWH. Symptomatic screening of conjunctival cancer in PLWH should be encouraged. Research on HPV involvement should remain a priority and EBV considered as another etiologic agent of interest. More studies on treatment modalities in PLWH should be considered.
Current Opinion in Infectious Diseases – Wolters Kluwer Health
Published: Feb 16, 2021
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