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Concordance Between Tissue Microarray and Whole-section Estrogen Receptor Expression and Intratumoral Heterogeneity

Concordance Between Tissue Microarray and Whole-section Estrogen Receptor Expression and... RESEARCH ARTICLE Concordance Between Tissue Microarray and Whole-section Estrogen Receptor Expression and Intratumoral Heterogeneity H. Evin Gulbahce, MD,* Roberto Gamez, MD, MPH,w Leah Dvorak, MD,z Colleen Forster, BS,z and Linda Varghese, MDy spective studies. Recently, tissue microarrays (TMA) have Abstract: Hormone receptor status determination for breast been widely used for evaluating a high number of cases at cancer is an important part of pathologists’ daily sign outs and lower cost that also provides more uniform analysis of many retrospective and prospective studies. In this study, we numerous cases in 1 block. The aim of this study is to compared the estrogen receptor (ER) expression tested on tissue determine whether estrogen receptor (ER) status of a core microarray (TMA) sections to those tested on whole sections biopsy is representative of ER status of the tumor based (WS) to find out concordance and frequency of intratumoral on whole section (WS). This is particularly important in heterogeneity. Five and one-half percent of all tumors showed patients undergoing neoadjuvant therapy in which no discrepancy in ER expression between TMA and WS. The rate residual tumor may be present to test or to confirm ER of discrepancy was lower with increasing number of cores http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Concordance Between Tissue Microarray and Whole-section Estrogen Receptor Expression and Intratumoral Heterogeneity

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Copyright
Copyright © 2012 by Lippincott Williams & Wilkins
ISSN
1541-2016
DOI
10.1097/PAI.0b013e318241ca14
pmid
22495371
Publisher site
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Abstract

RESEARCH ARTICLE Concordance Between Tissue Microarray and Whole-section Estrogen Receptor Expression and Intratumoral Heterogeneity H. Evin Gulbahce, MD,* Roberto Gamez, MD, MPH,w Leah Dvorak, MD,z Colleen Forster, BS,z and Linda Varghese, MDy spective studies. Recently, tissue microarrays (TMA) have Abstract: Hormone receptor status determination for breast been widely used for evaluating a high number of cases at cancer is an important part of pathologists’ daily sign outs and lower cost that also provides more uniform analysis of many retrospective and prospective studies. In this study, we numerous cases in 1 block. The aim of this study is to compared the estrogen receptor (ER) expression tested on tissue determine whether estrogen receptor (ER) status of a core microarray (TMA) sections to those tested on whole sections biopsy is representative of ER status of the tumor based (WS) to find out concordance and frequency of intratumoral on whole section (WS). This is particularly important in heterogeneity. Five and one-half percent of all tumors showed patients undergoing neoadjuvant therapy in which no discrepancy in ER expression between TMA and WS. The rate residual tumor may be present to test or to confirm ER of discrepancy was lower with increasing number of cores

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Jul 1, 2012

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