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ORIGINAL ARTICLE Computed Tomography Perfusion Analysis of Pancreatic Carcinoma Miriam Klauß, MD,* Wolfram Stiller, PhD,* Franziska Fritz,* Meinhard Kieser, PhD,Þ Jens Werner, MD,þ Hans-Ulrich Kauczor, MD,* and Lars Grenacher, MD* published on the differentiation between malignant processes Objective: The purpose of this study was to evaluate CT perfusion of and healthy tissues, for example, in liver lesions or for the eval- pancreatic carcinomas using the Patlak model for assessing perfusion, uation of hepatic cirrhosis. A recent study, for instance, showed permeability, and blood volume. that perfusion changes during fibrogenesis in chronic liver dis- Methods: A total of 25 patients with pancreatic carcinoma were ex- ease can be assessed using perfusion CT. In a first-ever study amined prospectively with a 64-slice computed tomography (CT) using a in 1995, Miles et al have shown the feasibility of pancreatic CT dynamic sequence after intravenous injection of 80-mL contrast mate- perfusion in patients with a normal pancreas as well as patients rial (370 mg/mL; flow rate, 5 mL/s). Eighty-kilovolt (peak) perfusion with pancreatic diseases. In the following years, the use of CT acquisitions were evaluated for estimating perfusion parameters for carci- perfusion data for identification of ischemic areas in malignant noma and healthy
Journal of Computer Assisted Tomography – Wolters Kluwer Health
Published: Mar 1, 2012
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