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H. Seismann, S. Blank, I. Braren, Kerstin Greunke, L. Cifuentes, T. Grunwald, R. Bredehorst, M. Ollert, E. Spillner (2010)
Dissecting cross-reactivity in hymenoptera venom allergy by circumvention of alpha-1,3-core fucosylation.Molecular immunology, 47 4
First report on the use of recombinant venom allergens for sIgE diagnostics using a routine test platform
S. Blank, S. Etzold, U. Darsow, M. Schiener, B. Eberlein, Dennis Russkamp, Sara Wolf, A. Graessel, T. Biedermann, M. Ollert, C. Schmidt‐Weber (2017)
Component-resolved evaluation of the content of major allergens in therapeutic extracts for specific immunotherapy of honeybee venom allergyHuman Vaccines & Immunotherapeutics, 13
Detailed study on the molecular composition of a number of therapeutic honeybee venom preparations confirming lack of Api m 10 and other allergens in some venom preparations
First report of a recombinant allergen form the Asian needle ant, which describes the relevance in patients with anaphylactic reactions
S. Blank, H. Seismann, Y. Michel, M. McIntyre, L. Cifuentes, I. Braren, Thomas Grunwald, Ulf Darsow, J. Ring, Reinhard Bredehorst, Markus Ollert, E. Spillner (2011)
Api m 10, a genuine A. mellifera venom allergen, is clinically relevant but underrepresented in therapeutic extractsAllergy, 66
R. Hamilton, P. Matsson, D. Hovanec-burns, M. Cleve, S. Chan, A. Kober, J. Kleine‐Tebbe, H. Renz, C. Magnusson, Ron Quicho, N. Adkinson (2015)
Analytical Performance Characteristics, Quality Assurance and Clinical Utility of Immunological Assays for Human IgE Antibodies of Defined Allergen Specificities. (CLSI-ILA20-A3)The Journal of Allergy and Clinical Immunology, 135
L. Skov, U. Seppälä, J. Coen, N. Crickmore, T. King, R. Monsalve, J. Kastrup, M. Spangfort, M. Gajhede (2006)
Structure of recombinant Ves v 2 at 2.0 Angstrom resolution: structural analysis of an allergenic hyaluronidase from wasp venom.Acta crystallographica. Section D, Biological crystallography, 62 Pt 6
D. Ebo, M. Faber, V. Sabato, J. Leysen, C. Bridts, L. Clerck (2013)
Component‐resolved diagnosis of wasp (yellow jacket) venom allergyClinical & Experimental Allergy, 43
P. Korošec, R. Valenta, I. Mittermann, Nina Čelesnik, M. Šilar, M. Zidarn, M. Košnik (2012)
High sensitivity of CAP-FEIA rVes v 5 and rVes v 1 for diagnosis of Vespula venom allergy.The Journal of allergy and clinical immunology, 129 5
P. Korošec, R. Erzen, M. Šilar, N. Bajrovič, P. Kopač, M. Košnik (2009)
Basophil responsiveness in patients with insect sting allergies and negative venom‐specific immunoglobulin E and skin prick test resultsClinical & Experimental Allergy, 39
(2011)
Detection of IgE to a panel of species specific allergens further improves discrimination of bee and wasp venom allergy
J. Huss‐Marp, M. Raulf, T. Jakob (2015)
Spiking with recombinant allergens to improve allergen extracts: benefits and limitations for the use in routine diagnosticsAllergo Journal International, 24
U. Jappe, M. Raulf‐Heimsoth, M. Hoffmann, G. Burow, C. Hübsch-Müller, A. Enk (2006)
In vitro hymenoptera venom allergy diagnosis: improved by screening for cross‐reactive carbohydrate determinants and reciprocal inhibitionAllergy, 61
B. Ruiz, P. Serrano, Miriam Verdú, Carmen Moreno (2015)
Sensitization to Api m 1, Api m 2, and Api m 4: association with safety of bee venom immunotherapy.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 114 4
T. Jakob, J. Köhler, S. Blank, U. Magnusson, J. Huss‐Marp, E. Spillner, J. Lidholm (2012)
Comparable IgE reactivity to natural and recombinant Api m 1 in cross-reactive carbohydrate determinant-negative patients with bee venom allergy.The Journal of allergy and clinical immunology, 130 1
S. Blank, H. Seismann, M. McIntyre, M. Ollert, Sara Wolf, F. Bantleon, E. Spillner (2013)
Vitellogenins Are New High Molecular Weight Components and Allergens (Api m 12 and Ves v 6) of Apis mellifera and Vespula vulgaris VenomPLoS ONE, 8
B. Ruiz, P. Serrano, Carmen Moreno (2016)
IgE-Api m 4 Is Useful for Identifying a Particular Phenotype of Bee Venom Allergy.Journal of investigational allergology & clinical immunology, 26 6
J. Köhler, S. Blank, S. Müller, F. Bantleon, M. Frick, J. Huss‐Marp, J. Lidholm, E. Spillner, T. Jakob (2014)
Component resolution reveals additional major allergens in patients with honeybee venom allergy.The Journal of allergy and clinical immunology, 133 5
M. Frick, J. Fischer, A. Helbling, F. Ruëff, D. Wieczorek, M. Ollert, W. Pfützner, S. Müller, J. Huss‐Marp, Britta Dorn, T. Biedermann, J. Lidholm, G. Ruecker, F. Bantleon, M. Miehe, E. Spillner, T. Jakob (2016)
Predominant Api m 10 sensitization as risk factor for treatment failure in honey bee venom immunotherapy.The Journal of allergy and clinical immunology, 138 6
S. Hofmann, N. Pfender, S. Weckesser, J. Huss‐Marp, T. Jakob (2011)
Added value of IgE detection to rApi m 1 and rVes v 5 in patients with Hymenoptera venom allergy.The Journal of allergy and clinical immunology, 127 1
L. Arzt, D. Bokanovic, C. Schrautzer, I. Schwarz, K. Laipold, W. Aberer, G. Sturm (2017)
Questionable diagnostic benefit of the commercially available panel of bee venom componentsAllergy, 72
B. Vos, J. Köhler, S. Müller, E. Stretz, F. Ruëff, T. Jakob (2013)
Spiking venom with rVes v 5 improves sensitivity of IgE detection in patients with allergy to Vespula venom.The Journal of allergy and clinical immunology, 131 4
K. Jeong, Myung-Hee Yi, M. Son, Dongpyo Lyu, Jae-Hyun Lee, T. Yong, Jungwon Park (2016)
IgE Reactivity of Recombinant Pac c 3 from the Asian Needle Ant (Pachycondyla chinensis)International Archives of Allergy and Immunology, 169
Wolfgang Hemmer, M. Focke, D. Kolarich, Iain Wilson, Friedrich Altmann, Stefan Wöhrl, Manfred Götz, R. Jarisch (2001)
Antibody binding to venom carbohydrates is a frequent cause for double positivity to honeybee and yellow jacket venom in patients with stinging-insect allergy.The Journal of allergy and clinical immunology, 108 6
A. Leimgruber, J. Lantin, P. Frei (1993)
Comparison of two in vitro assays, RAST and CAP, when applied to the diagnosis of anaphylactic reactions to honeybee or yellow jacket venomsAllergy, 48
C. Jin, M. Focke, R. Léonard, R. Jarisch, F. Altmann, W. Hemmer (2010)
Reassessing the role of hyaluronidase in yellow jacket venom allergy.The Journal of allergy and clinical immunology, 125 1
U. Müller, P. Schmid‐Grendelmeier, O. Hausmann, A. Helbling (2012)
IgE to recombinant allergens Api m 1, Ves v 1, and Ves v 5 distinguish double sensitization from crossreaction in venom allergyAllergy, 67
Description of the production of Poly p 1 in recombinant form and discussion of the problem of cross-reactivity of allergens from a variety of wasp species not known in Europe and Northern America
J. Šelb, R. Kogovšek, M. Šilar, M. Košnik, P. Korošec (2016)
Improved recombinant Api m 1‐ and Ves v 5‐based IgE testing to dissect bee and yellow jacket allergy and their correlation with the severity of the sting reactionClinical & Experimental Allergy, 46
R. Monsalve, A. Vega, L. Marqués, A. Miranda, J. Fernández, Vincent Soriano, S. Cruz, C. Domínguez-Noche, L. Sánchez‐Morillas, M. Armisen‐Gil, R. Guspi, D. Barber (2012)
Component‐resolved diagnosis of vespid venom‐allergic individuals: phospholipases and antigen 5s are necessary to identify Vespula or Polistes sensitizationAllergy, 67
Jiaying Zhu (2016)
Deciphering the main venom components of the ectoparasitic ant-like bethylid wasp, Scleroderma guani.Toxicon : official journal of the International Society on Toxinology, 113
J. Kleine‐Tebbe, T. Jakob (2015)
Molecular allergy diagnostics using IgE singleplex determinations: methodological and practical considerations for use in clinical routineAllergo Journal International, 24
A. Perez-Riverol, F. Pereira, Alexis Lasa, Luís Fernandes, J. Santos-Pinto, Débora Justo-Jacomini, Gabriel Azevedo, M. Bazon, M. Palma, R. Zollner, M. Brochetto-Braga (2016)
Molecular cloning, expression and IgE-immunoreactivity of phospholipase A1, a major allergen from Polybia paulista (Hymenoptera: Vespidae) venom.Toxicon : official journal of the International Society on Toxinology, 124
P. Szecsi, S. Stender (2013)
Comparison of Immunoglobulin E Measurements on IMMULITE and ImmunoCAP in Samples Consisting of Allergen-Specific Mouse-Human Chimeric Monoclonal Antibodies towards Allergen Extracts and Four Recombinant AllergensInternational Archives of Allergy and Immunology, 162
D. Golden, J. Demain, T. Freeman, D. Graft, M. Tankersley, J. Tracy, J. Blessing-Moore, D. Bernstein, C. Dinakar, M. Greenhawt, David Khan, D. Lang, R. Nicklas, J. Oppenheimer, J. Portnoy, C. Randolph, D. Schuller, D. Wallace (2017)
Stinging insect hypersensitivity: A practice parameter update 2016.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 118 1
D. Rafei-Shamsabadi, S. Müller, W. Pfützner, E. Spillner, F. Ruëff, T. Jakob (2014)
Recombinant allergens rarely allow identification of Hymenoptera venom-allergic patients with negative specific IgE to whole venom preparations.The Journal of allergy and clinical immunology, 134 2
H. Seismann, S. Blank, L. Cifuentes, I. Braren, R. Bredehorst, T. Grunwald, M. Ollert, E. Spillner (2010)
Recombinant phospholipase A1 (Ves v 1) from yellow jacket venom for improved diagnosis of hymenoptera venom hypersensitivityClinical and Molecular Allergy : CMA, 8
U. Müller, N. Johansen, A. Petersen, J. Fromberg-Nielsen, G. Haeberli (2009)
Hymenoptera venom allergy: analysis of double positivity to honey bee and Vespula venom by estimation of IgE antibodies to species‐specific major allergens Api m1 and Ves v5Allergy, 64
G. Sturm, M. Bilò, P. Bonadonna, W. Hemmer, B. Caruso, D. Bokanovic, W. Aberer (2012)
Ves v 5 can establish the diagnosis in patients without detectable specific IgE to wasp venom and a possible north-south difference in Api m 1 sensitization in Europe.The Journal of allergy and clinical immunology, 130 3
T. Jakob, S. Blank, E. Spillner (2017)
Benefits and Limitations of Recombinant Allergens in Diagnostics of Insect Venom Allergy
L. Cifuentes, Sebastian Vosseler, S. Blank, H. Seismann, D. Pennino, U. Darsow, R. Bredehorst, J. Ring, M. Mempel, E. Spillner, M. Ollert (2014)
Identification of Hymenoptera venom-allergic patients with negative specific IgE to venom extract by using recombinant allergens.The Journal of allergy and clinical immunology, 133 3
C. Schrautzer, D. Bokanovic, W. Hemmer, R. Lang, T. Hawranek, I. Schwarz, W. Aberer, E. Sturm, G. Sturm (2016)
Sensitivity and specificity of Hymenoptera allergen components depend on the diagnostic assay employed.The Journal of allergy and clinical immunology, 137 5
J. Moffitt, D. Golden, R. Reisman, Rufus Lee, R. Nicklas, T. Freeman, R. deShazo, J. Tracy, I. Bernstein, J. Blessing-Moore, D. Khan, D. Lang, J. Portnoy, D. Schuller, S. Spector, S. Tilles (2004)
Stinging insect hypersensitivity: a practice parameter update.The Journal of allergy and clinical immunology, 114 4
S. Blank, H. Seismann, B. Bockisch, I. Braren, L. Cifuentes, M. McIntyre, Dana Rühl, J. Ring, R. Bredehorst, M. Ollert, T. Grunwald, E. Spillner (2010)
Identification, Recombinant Expression, and Characterization of the 100 kDa High Molecular Weight Hymenoptera Venom Allergens Api m 5 and Ves v 3The Journal of Immunology, 184
Report on different sensitivities of different assay formats for detection of sIgE to Api m 1 and Ves v 5, which considers differences in the heterologous calibration for sIgE of the analysed systems
M. Frick, S. Müller, F. Bantleon, J. Huss‐Marp, J. Lidholm, E. Spillner, T. Jakob (2015)
rApi m 3 and rApi m 10 improve detection of honey bee sensitization in Hymenoptera venom‐allergic patients with double sensitization to honey bee and yellow jacket venomAllergy, 70
R. Wood, N. Segall, S. Ahlstedt, P. Williams (2007)
Accuracy of IgE antibody laboratory results.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 99 1
T. Jakob, D. Rafei-Shamsabadi, E. Spillner, S. Müller (2017)
Diagnostics in Hymenoptera venom allergy: current concepts and developments with special focus on molecular allergy diagnosticsAllergo Journal International, 26
P. Korošec, M. Šilar, R. Erzen, Nina Čelesnik, N. Bajrovič, M. Zidarn, M. Košnik (2013)
Clinical Routine Utility of Basophil Activation Testing for Diagnosis of Hymenoptera-Allergic Patients with Emphasis on Individuals with Negative Venom-Specific IgE AntibodiesInternational Archives of Allergy and Immunology, 161
S. Blank, C. Neu, Daniel Hasche, F. Bantleon, T. Jakob, E. Spillner (2013)
Polistes species venom is devoid of carbohydrate-based cross-reactivity and allows interference-free diagnostics.The Journal of allergy and clinical immunology, 131 4
P. Korošec, R. Valenta, I. Mittermann, Nina Čelesnik, R. Erzen, M. Zidarn, M. Košnik (2011)
Low sensitivity of commercially available rApi m 1 for diagnosis of honeybee venom allergy.The Journal of allergy and clinical immunology, 128 3
G. Sturm, W. Hemmer, T. Hawranek, R. Lang, M. Ollert, E. Spillner, S. Blank, D. Bokanovic, W. Aberer (2011)
Detection of IgE to recombinant Api m 1 and rVes v 5 is valuable but not sufficient to distinguish bee from wasp venom allergy.The Journal of allergy and clinical immunology, 128 1
G. Sturm, C. Jin, B. Kranzelbinder, W. Hemmer, E. Sturm, A. Griesbacher, A. Heinemann, J. Vollmann, F. Altmann, K. Crailsheim, M. Focke, W. Aberer (2011)
Inconsistent Results of Diagnostic Tools Hamper the Differentiation between Bee and Vespid Venom AllergyPLoS ONE, 6
W. Hemmer, M. Focke, D. Kolarich, I. Dalik, Manfred Götz, R. Jarisch (2004)
Identification by immunoblot of venom glycoproteins displaying immunoglobulin E‐binding N‐glycans as cross‐reactive allergens in honeybee and yellow jacket venomClinical & Experimental Allergy, 34
Débora Jacomini, Susana Moreira, F. Pereira, R. Zollner, M. Braga (2014)
Reactivity of IgE to the allergen hyaluronidase from Polybia paulista (Hymenoptera, Vespidae) venom.Toxicon : official journal of the International Society on Toxinology, 82
Purpose of reviewComponent-resolved diagnostics makes use of defined allergen molecules to analyse IgE-mediated sensitizations at a molecular level. Here, we review recent studies on the use of component-resolved diagnostics in the field of Hymenoptera venom allergy (HVA) and discuss its benefits and limitations.Recent findingsComponent resolution in HVA has moved from single molecules to panels of allergens. Detection of specific immunoglobulin E (sIgE) to marker and cross-reactive venom allergens has been reported to facilitate the discrimination between primary sensitization and cross-reactivity and thus, to provide a better rationale for prescribing venom immunotherapy (VIT), particularly in patients sensitized to both honeybee and vespid venom. Characterization of IgE reactivity to a broad panel of venom allergens has allowed the identification of different sensitization profiles that in honeybee venom allergy were associated with increased risks for side effects or treatment failure of VIT. In contrast, component resolution so far has failed to provide reliable markers for the discrimination of sensitizations to venoms of different members of Vespidae.SummaryComponent-resolved diagnostics allows a better understanding of the complexity of sensitization and cross-reactivities in HVA. In addition, the enhanced resolution and precision may allow identification of biomarkers, which can be used for risk stratification in VIT. Knowledge about the molecular composition of different therapeutic preparations may enable the selection of appropriate preparations for VIT according to individual sensitization profiles, an approach consistent with the goals of personalized medicine.
Current Opinion in Allergy and Clinical Immunology – Wolters Kluwer Health
Published: Oct 1, 2017
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