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Comparison of 50% Dextrose Water, 25% Mannitol, and 23.5% Saline for the Treatment of Hemodialysis‐associated Muscle Cramps

Comparison of 50% Dextrose Water, 25% Mannitol, and 23.5%... Hypertonic solutions of dextrose (D), mannitol (M), and saline (S) are effecive treatments for hemodialysis-associated muscle cramps, but have not been directly compared to one another. Concern exists that postdialysis retention of M and S may lead to increased thirst, interdialytic weight pain (IDWG), and elevated blood pressure. The authors performed a prospective, randomized, double-blind crossover study to compare the efficacy of D, M, and S in 24 chronic hemodialysis patients. Cramps were treated with 50 ml (126 mOsm) D, 100 ml (138 mOsm) M, and 16 ml (126 mOsm) S. All patients were assigned to each regimen for a 2 week period. For the entire patient group (n = 24), mean cramp duration (± SD) was less for M compared to D (9 ± 5 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png ASAIO Transactions Wolters Kluwer Health

Comparison of 50% Dextrose Water, 25% Mannitol, and 23.5% Saline for the Treatment of Hemodialysis‐associated Muscle Cramps

ASAIO Transactions , Volume 37 (4) – Oct 1, 1991

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ISSN
0889-7190

Abstract

Hypertonic solutions of dextrose (D), mannitol (M), and saline (S) are effecive treatments for hemodialysis-associated muscle cramps, but have not been directly compared to one another. Concern exists that postdialysis retention of M and S may lead to increased thirst, interdialytic weight pain (IDWG), and elevated blood pressure. The authors performed a prospective, randomized, double-blind crossover study to compare the efficacy of D, M, and S in 24 chronic hemodialysis patients. Cramps were treated with 50 ml (126 mOsm) D, 100 ml (138 mOsm) M, and 16 ml (126 mOsm) S. All patients were assigned to each regimen for a 2 week period. For the entire patient group (n = 24), mean cramp duration (± SD) was less for M compared to D (9 ± 5

Journal

ASAIO TransactionsWolters Kluwer Health

Published: Oct 1, 1991

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