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Coinhibitory receptors and CD8 T cell exhaustion in chronic infections

Coinhibitory receptors and CD8 T cell exhaustion in chronic infections REVIEW URRENT Coinhibitory receptors and CD8 T cell exhaustion in PINION chronic infections a a b Vijay K. Kuchroo , Ana C. Anderson , and Constantinos Petrovas Purpose of review To describe the recent data on the role of coinhibitory receptors, such as PD-1, Tim-3, CD160, as mediators of the ‘exhaustion’ of virus-specific CD8 T cells in chronic infections and particularly in HIV. Recent findings Exhaustion of chronic virus-specific CD8 T cells is a dynamic process characterized by altered differentiation, impaired function, and compromised proliferation/survival profile of these cells. This process is mediated by coinhibitory receptors expressed on the surface of virus-specific CD8 T cells and an orchestrated function of centrally connected pathways. Coexpression of several coinhibitory receptors characterizes severely exhausted virus-specific CD8 T cells. Several studies suggest a synergistic action, instead of a redundant role, of the different receptors. In-vivo manipulation of the coinhibitory network can rejuvenate exhausted virus-specific CD8 T cell responses and constrain replication of chronic viruses, including HIV. Summary Revealing the molecular basis of virus-specific CD8 T cell exhaustion in chronic infections is critical for the understanding of the disease pathogenesis and the designing of novel vaccines aiming to enhance the cytolytic arm of the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and Aids Wolters Kluwer Health

Coinhibitory receptors and CD8 T cell exhaustion in chronic infections

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Copyright
© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins
ISSN
1746-630X
eISSN
1746-6318
DOI
10.1097/COH.0000000000000088
pmid
25010894
Publisher site
See Article on Publisher Site

Abstract

REVIEW URRENT Coinhibitory receptors and CD8 T cell exhaustion in PINION chronic infections a a b Vijay K. Kuchroo , Ana C. Anderson , and Constantinos Petrovas Purpose of review To describe the recent data on the role of coinhibitory receptors, such as PD-1, Tim-3, CD160, as mediators of the ‘exhaustion’ of virus-specific CD8 T cells in chronic infections and particularly in HIV. Recent findings Exhaustion of chronic virus-specific CD8 T cells is a dynamic process characterized by altered differentiation, impaired function, and compromised proliferation/survival profile of these cells. This process is mediated by coinhibitory receptors expressed on the surface of virus-specific CD8 T cells and an orchestrated function of centrally connected pathways. Coexpression of several coinhibitory receptors characterizes severely exhausted virus-specific CD8 T cells. Several studies suggest a synergistic action, instead of a redundant role, of the different receptors. In-vivo manipulation of the coinhibitory network can rejuvenate exhausted virus-specific CD8 T cell responses and constrain replication of chronic viruses, including HIV. Summary Revealing the molecular basis of virus-specific CD8 T cell exhaustion in chronic infections is critical for the understanding of the disease pathogenesis and the designing of novel vaccines aiming to enhance the cytolytic arm of the

Journal

Current Opinion in HIV and AidsWolters Kluwer Health

Published: Sep 1, 2014

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