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ORIGINAL ARTICLE Co-Overexpression of Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1 Adversely Affects the Postoperative Survival in Non-small Cell Lung Cancer Yu-Chung Wu, MD,*† Li-Jen Su, PhD,‡ Hao-Wei Wang, MD,*† Chien-Fu Jeff Lin, MD, PhD,§ Wen-Hu Hsu, MD,*† Teh-Ying Chou, MD, PhD,† Chi-Ying F. Huang, PhD,† Chia-Li Lu, MS,¶ and Chung-Tsen Hsueh, MD, PhD# Conclusions: Overexpression of either COX-2 or mPGES-1 is Introduction: Cyclooxygenase (COX)-2 and microsomal prosta- common but unrelated in NSCLC. Co-overexpression of both glandin E synthase (mPGES)-1 have been found to be overexpressed COX-2 and mPGES-1 adversely affects postoperative overall and in non-small cell lung cancer (NSCLC). The aim of this study was disease-free survivals. to investigate the expression profiles of COX-2 and mPGES-1 and Key Words: Non-small cell lung cancer, Cyclooxygenase-2, Mi- their correlation with the clinical characteristics and survival out- crosomal prostaglandin E synthase-1, Survival. comes in patients with resected NSCLC. Methods/Results: Seventy-nine paired adjacent normal-tumor (J Thorac Oncol. 2010;5: 1167–1174) matched samples were prospectively procured from patients under- going surgery for NSCLC. The protein levels of COX-2 and mPGES-1 were assessed by Western blot analysis. Overexpression ung cancer is the leading cause of cancer death among in the tumor sample was defined as more
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Aug 1, 2010
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