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ORIGINAL ARTICLE Clinical Characteristics and Treatment Outcomes of Lung Adenocarcinomas with Discrepant EGFR Mutation Testing Results Derived from PCR-Direct Sequencing and Real-Time PCR-Based Assays Chao-Hua Chiu, MD,*†‡ Hsiang-Ling Ho, PhD,§ Chi-Lu Chiang, MD,‡ Shiou-Fu Lin, MD,║ Hsiu-Hsun Ma, MS,§ Yu-Ting Chuang, MS,§ Kun-Yang Lin, MS,§ Chun-Ming Tsai, MD,†‡ and Teh-Ying Chou, MD, PhD*§ Conclusions: DS overlooked EGFR mutation in a significant number Introduction: Detection of epidermal growth factor receptor (EGFR) of lung adenocarcinoma patients. These patients could have obtained mutation has become the most critical molecular test in managing the same benefit from EGFR-TKI when a high-sensitivity method patients with advanced lung adenocarcinoma. Whether patients with such as Scorpion/ARMS was applied. discrepant EGFR mutation results determined by low- and high-sen- sitivity methods have different clinical outcomes with EGFR tyrosine Key Words: Lung adenocarcinoma, Epidermal growth factor recep- kinase inhibitor (TKI) treatment needs to be further evaluated. tor, Mutation, Tyrosine kinase inhibitor. Methods: Genomic DNA from serial lung adenocarcinoma samples (J Thorac Oncol. 2014;9: 91–96) that were EGFR wild-type determined by direct sequencing (DS) were reanalyzed using Scorpion/Amplification Refractory Mutation System (ARMS). The outcomes with EGFR-TKI treatment among pidermal growth factor receptor (EGFR), a transmem- patients with discrepant EGFR mutation results between DS and Ebrane receptor tyrosine kinase, is frequently overexpressed Scorpion/ARMS versus patients with EGFR mutations detected
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Jan 1, 2014
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