Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Changes in HIV reservoirs during long-term antiretroviral therapy

Changes in HIV reservoirs during long-term antiretroviral therapy REVIEW URRENT Changes in HIV reservoirs during long-term PINION antiretroviral therapy Feiyu F. Hong and John W. Mellors Purpose of review To review current knowledge about the impact of long-term combination antiretroviral therapy (cART) on HIV reservoirs. Recent findings The number of HIV-infected cells that persist during long-term antiretroviral therapy is associated with the stage of HIV infection at the time of treatment initiation. Initiation of cART reduces the number of infected cells over the first 4 years of therapy, but thereafter there is no further decline despite long-term effective cART. The remarkable stability of infected cell numbers is likely due to a balance among homeostatic or antigen-driven proliferation of infected memory T-cells subsets, clonal expansion of a subset of infected cells as a consequence of specific retroviral integration sites, and death of other infected cells. At present, there is no effective means of accelerating the decay of infected cells in individuals initiated on cART during chronic HIV infection. Summary Given the stability and difficulty in eliminating HIV-infected cells, early initiation of cART in treatment-naı¨ve HIV-infected patients is currently the most effective way to limit the size and diversity of HIV reservoirs. Keywords antiretroviral therapy, gut-associated lymphoid tissue, latent http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and Aids Wolters Kluwer Health

Changes in HIV reservoirs during long-term antiretroviral therapy

Mellors, John W.
Current Opinion in HIV and Aids , Volume 10 (1) – Jan 1, 2015
Download PDF
6 pages

Loading next page...
 
/lp/wolters-kluwer-health/changes-in-hiv-reservoirs-during-long-term-antiretroviral-therapy-4lRwDv6uI0

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Copyright
© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins
ISSN
1746-630X
eISSN
1746-6318
DOI
10.1097/COH.0000000000000119
pmid
25402706
Publisher site
See Article on Publisher Site

Abstract

REVIEW URRENT Changes in HIV reservoirs during long-term PINION antiretroviral therapy Feiyu F. Hong and John W. Mellors Purpose of review To review current knowledge about the impact of long-term combination antiretroviral therapy (cART) on HIV reservoirs. Recent findings The number of HIV-infected cells that persist during long-term antiretroviral therapy is associated with the stage of HIV infection at the time of treatment initiation. Initiation of cART reduces the number of infected cells over the first 4 years of therapy, but thereafter there is no further decline despite long-term effective cART. The remarkable stability of infected cell numbers is likely due to a balance among homeostatic or antigen-driven proliferation of infected memory T-cells subsets, clonal expansion of a subset of infected cells as a consequence of specific retroviral integration sites, and death of other infected cells. At present, there is no effective means of accelerating the decay of infected cells in individuals initiated on cART during chronic HIV infection. Summary Given the stability and difficulty in eliminating HIV-infected cells, early initiation of cART in treatment-naı¨ve HIV-infected patients is currently the most effective way to limit the size and diversity of HIV reservoirs. Keywords antiretroviral therapy, gut-associated lymphoid tissue, latent

Journal

Current Opinion in HIV and Aids – Wolters Kluwer Health

Published: Jan 1, 2015

There are no references for this article.