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Downloaded from http://journals.lww.com/co-hivandaids by BhDMf5ePHKbH4TTImqenVJ2toCr/9wZZjwPUWvYES9l2nY+zyylnl33NGMK6MRsx on 10/02/2020 REVIEW URRENT Challenges and opportunities for hepatitis B cure PINION in the setting of HIV–hepatitis B virus co-infection a b,c Jennifer Audsley and Joe Sasadeusz Purpose of review To examine issues specific to HIV–HBV co-infection that are relevant to the search for and achieving hepatitis B cure in this the setting Recent findings In HIV–HBV co-infection, high rates of hepatitis B surface antigen (HBsAg) loss early after initiation of HBV- active antiretroviral therapy (ART) have previously been reported. Between 2012 and 2016, HBsAg loss from 2.8 to 23% was reported in numerous studies, including those already on suppressive HBV-active ART. Data published in 2018–2019 show that these rates have remained fairly stable (3.0–13.9%). However, it appears that higher HBsAg loss on starting HBV-active ART in co-infection falls within a few years to levels similar to that observed in long-term treated HBV mono-infection. Immune reconstitution and CD4þ T-cell recovery are likely to play a role in high HBsAg loss rates seen in early treated co-infection, although the mechanisms driving this are yet to be fully elucidated. Summary High rates of HBsAg loss early after HBV-active ART initiation is unique to HIV–HBV co-infection, making
Current Opinion in HIV & AIDS – Wolters Kluwer Health
Published: May 1, 2020
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