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Cell Talk A Phenomenon Observed in the Keloid Scar by Immunohistochemical Study

Cell Talk A Phenomenon Observed in the Keloid Scar by Immunohistochemical Study RESEARCH ARTICLE Cell Talk: A Phenomenon Observed in the Keloid Scar by Immunohistochemical Study Soad Ali Shaker, MD,* Nasra Naeim Ayuob, MD,* and Nahid Hassan Hajrah, PhDw response to trauma, inflammation, surgery, or burns and Abstract: Keloid is a common complication of the wound occasionally seem to occur spontaneously. Both keloid healing process. Scarce histologic studies describing changes in and hypertrophic scars are characterized by an abundant keloid growth or progression, regarding detailed descriptions of disposition of collagen and glycoprotein. cellular distribution, relationship, or interaction are available. The presence of special types of inflammatory or This study aimed to describe the nature, types, and interactions immune cells (especially lymphocytes, macrophages, and of immune cells (lymphocytes, macrophages, and mast cells), increasing number of mast cells) and their relationship 1–3 which predominate in keloid complications and may play a role to active fibroblasts were among the amazing and in fibroblastic activation. In this study, 44 samples of keloid interesting histologic changes that were observed. These were collected, processed, and examined using both light histologic changes pose a great conflict to most investiga- (including routine and immunocytochemical staining) and tions concerning which of these cells were the initiators of scanning electron microscopy http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Cell Talk A Phenomenon Observed in the Keloid Scar by Immunohistochemical Study

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Copyright
Copyright #x00A9; 2011 by Lippincott Williams & Wilkins
ISSN
1541-2016
DOI
10.1097/PAI.0b013e3181efa2ef
pmid
20881838
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Cell Talk: A Phenomenon Observed in the Keloid Scar by Immunohistochemical Study Soad Ali Shaker, MD,* Nasra Naeim Ayuob, MD,* and Nahid Hassan Hajrah, PhDw response to trauma, inflammation, surgery, or burns and Abstract: Keloid is a common complication of the wound occasionally seem to occur spontaneously. Both keloid healing process. Scarce histologic studies describing changes in and hypertrophic scars are characterized by an abundant keloid growth or progression, regarding detailed descriptions of disposition of collagen and glycoprotein. cellular distribution, relationship, or interaction are available. The presence of special types of inflammatory or This study aimed to describe the nature, types, and interactions immune cells (especially lymphocytes, macrophages, and of immune cells (lymphocytes, macrophages, and mast cells), increasing number of mast cells) and their relationship 1–3 which predominate in keloid complications and may play a role to active fibroblasts were among the amazing and in fibroblastic activation. In this study, 44 samples of keloid interesting histologic changes that were observed. These were collected, processed, and examined using both light histologic changes pose a great conflict to most investiga- (including routine and immunocytochemical staining) and tions concerning which of these cells were the initiators of scanning electron microscopy

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Mar 1, 2011

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