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Cell Membrane Reactivity of MIB-1 Antibody to Ki67 in Human Tumors: Fact or Artifact?

Cell Membrane Reactivity of MIB-1 Antibody to Ki67 in Human Tumors: Fact or Artifact? TECHNICAL ARTICLE Cell Membrane Reactivity of MIB-1 Antibody to Ki67 in Human Tumors: Fact or Artifact? Eugenio Leonardo, MD,* Marco Volante, MD,w Mattia Barbareschi, MD,z Alberto Cavazza, MD,y Angelo Paolo Dei Tos, MD,J Gianni Bussolati, MD FRCPath,z and Mauro Papotti, MDw t is well known that the nuclear Ki67 antigen Abstract: Ki67 immunohistochemistry is a widely used marker of Iis expressed during all cell cycle phases, but G . Ki67 the tumor proliferative fraction. Apart from the nuclear staining immunostaining is therefore the most common histo- of dividing cells, MIB-1 monoclonal antibody was also found to pathologic method to assess the tumor cell proliferation stain the cell membrane of some tumor types. Indeed, such index (PI), in routine formalin-fixed paraffin-embedded membrane reactivity was proposed as a diagnostic feature of samples. In the literature, several studies have been hyalinizing trabecular tumor (HTT) of the thyroid. To verify the reported on the prognostic role of the PI in neo- diagnostic role of Ki67 membrane pattern, 6 HTTs, 8 pulmonary plastic patients. The survival rate correlates with the sclerosing hemangiomas (SH), and 6 other human tumors with percentage of Ki67 positive neoplastic cell of larynx, 3,4 MIB-1 cell membrane immunoreactivity were stained http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Cell Membrane Reactivity of MIB-1 Antibody to Ki67 in Human Tumors: Fact or Artifact?

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ISSN
1541-2016
DOI
10.1097/01.pai.0000213122.66096.f0
pmid
17525638
Publisher site
See Article on Publisher Site

Abstract

TECHNICAL ARTICLE Cell Membrane Reactivity of MIB-1 Antibody to Ki67 in Human Tumors: Fact or Artifact? Eugenio Leonardo, MD,* Marco Volante, MD,w Mattia Barbareschi, MD,z Alberto Cavazza, MD,y Angelo Paolo Dei Tos, MD,J Gianni Bussolati, MD FRCPath,z and Mauro Papotti, MDw t is well known that the nuclear Ki67 antigen Abstract: Ki67 immunohistochemistry is a widely used marker of Iis expressed during all cell cycle phases, but G . Ki67 the tumor proliferative fraction. Apart from the nuclear staining immunostaining is therefore the most common histo- of dividing cells, MIB-1 monoclonal antibody was also found to pathologic method to assess the tumor cell proliferation stain the cell membrane of some tumor types. Indeed, such index (PI), in routine formalin-fixed paraffin-embedded membrane reactivity was proposed as a diagnostic feature of samples. In the literature, several studies have been hyalinizing trabecular tumor (HTT) of the thyroid. To verify the reported on the prognostic role of the PI in neo- diagnostic role of Ki67 membrane pattern, 6 HTTs, 8 pulmonary plastic patients. The survival rate correlates with the sclerosing hemangiomas (SH), and 6 other human tumors with percentage of Ki67 positive neoplastic cell of larynx, 3,4 MIB-1 cell membrane immunoreactivity were stained

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Jun 1, 2007

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