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Cell exhaustion in HIV-1 infection role of suppressor cells

Cell exhaustion in HIV-1 infection role of suppressor cells REVIEW URRENT Cell exhaustion in HIV-1 infection: role of PINION suppressor cells a,b,c, a,b,c, d Nabila Seddiki , Vedran Brezar , and Rika Draenert Purpose of review Suppressor cells regulate immune responses during chronic viral infection by limiting immunopathology associated with inflammation and immune activation. This dampening of adaptive immune responses can be harmful in HIV-1 infection as it also prevents the immune system from clearing the virus, leading to viral persistence and prolonged antigen expression that often leads to immune exhaustion. A current priority is to find the best strategy to target and manipulate key molecules such as CD39 that suppress anti-HIV-1 immune responses. Recent findings New suppressor cell subsets and cellular markers have been identified and characterized in the past years. We are able to identify and measure regulatory T cells, regulatory B cells and myeloid-derived suppressor cells in HIV-1-infected patients. We can also measure antigen-specific regulatory T cells in patients, which is a valuable step forward. Targeting HIV-1-specific regulatory T cells could be beneficial if we aim to manipulate key inhibitory molecules such as CTLA-4 and/or PD-1 that have already proven their efficacy in cancer. New other possible targets to take into account are CD39 and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and Aids Wolters Kluwer Health

Cell exhaustion in HIV-1 infection role of suppressor cells

Draenert, Rika
Current Opinion in HIV and Aids , Volume 9 (5) – Sep 1, 2014
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Copyright
© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins
ISSN
1746-630X
eISSN
1746-6318
DOI
10.1097/COH.0000000000000087
pmid
25010895
Publisher site
See Article on Publisher Site

Abstract

REVIEW URRENT Cell exhaustion in HIV-1 infection: role of PINION suppressor cells a,b,c, a,b,c, d Nabila Seddiki , Vedran Brezar , and Rika Draenert Purpose of review Suppressor cells regulate immune responses during chronic viral infection by limiting immunopathology associated with inflammation and immune activation. This dampening of adaptive immune responses can be harmful in HIV-1 infection as it also prevents the immune system from clearing the virus, leading to viral persistence and prolonged antigen expression that often leads to immune exhaustion. A current priority is to find the best strategy to target and manipulate key molecules such as CD39 that suppress anti-HIV-1 immune responses. Recent findings New suppressor cell subsets and cellular markers have been identified and characterized in the past years. We are able to identify and measure regulatory T cells, regulatory B cells and myeloid-derived suppressor cells in HIV-1-infected patients. We can also measure antigen-specific regulatory T cells in patients, which is a valuable step forward. Targeting HIV-1-specific regulatory T cells could be beneficial if we aim to manipulate key inhibitory molecules such as CTLA-4 and/or PD-1 that have already proven their efficacy in cancer. New other possible targets to take into account are CD39 and

Journal

Current Opinion in HIV and Aids – Wolters Kluwer Health

Published: Sep 1, 2014

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