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CD44 Immunoreactivity in Soft‐Tissue Sarcomas

CD44 Immunoreactivity in Soft‐Tissue Sarcomas The CD44 antigen is commonly expressed by a wide variety of human lymphoid and epithelial cell types and tumors. Because one ligand of this receptor moiety appears to be stromal hyaluronic acid, we hypothesized that CD44 immunoreactivity might characterize selected mesenchymal neoplasms as well. Sections from 112 soft-tissue sarcomas (32 malignant fibrous histiocytomas, 26 leiomyosarcomas, 15 malignant peripheral nerve sheath tumors, 14 liposarcomas, eight synovial sarcomas, four epithelioid sarcomas, three clear-cell sarcomas, six angiosarcomas, and four alveolar soft-part sarcomas) were stained with the CD44 antibody A1G3. Membrane accentuation and exclusive cytoplasmic reactivity were recorded as separate staining patterns. All angiosarcomas, epithelioid sarcomas, and alveolar soft-part sarcomas were positive; of these, all but two exhibited cytoplasmic staining. Cytoplasmic positivity was also found in the epithelial elements of four synovial sarcomas, whereas the spindle cells were negative. Lipoblastic and melanocytic neoplasms were also negative for CD44. Membrane accentuation was observed in nine of 20 CD44-reactive leiomyosarcomas, whereas 10 of 11 positive nerve-sheath neoplasms manifested cytoplasmic staining, suggesting differences in cellularstromal interactions in these types of sarcomas. Variable patterns of reactivity in “malignant fibrous histiocytomas” appear to support an inherent heterogeneity in this class of tumors. Overall, these data indicate a wide distribution of CD44-antigen expression among soft-tissue tumors with some distinctive patterns of expression that may be useful in characterizing such neoplasms. However, CD44 staining may have only a limited role in resolving the differential diagnoses of epithelioid neoplasms. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

CD44 Immunoreactivity in Soft‐Tissue Sarcomas

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ISSN
1062-3345
eISSN
1533-4058

Abstract

The CD44 antigen is commonly expressed by a wide variety of human lymphoid and epithelial cell types and tumors. Because one ligand of this receptor moiety appears to be stromal hyaluronic acid, we hypothesized that CD44 immunoreactivity might characterize selected mesenchymal neoplasms as well. Sections from 112 soft-tissue sarcomas (32 malignant fibrous histiocytomas, 26 leiomyosarcomas, 15 malignant peripheral nerve sheath tumors, 14 liposarcomas, eight synovial sarcomas, four epithelioid sarcomas, three clear-cell sarcomas, six angiosarcomas, and four alveolar soft-part sarcomas) were stained with the CD44 antibody A1G3. Membrane accentuation and exclusive cytoplasmic reactivity were recorded as separate staining patterns. All angiosarcomas, epithelioid sarcomas, and alveolar soft-part sarcomas were positive; of these, all but two exhibited cytoplasmic staining. Cytoplasmic positivity was also found in the epithelial elements of four synovial sarcomas, whereas the spindle cells were negative. Lipoblastic and melanocytic neoplasms were also negative for CD44. Membrane accentuation was observed in nine of 20 CD44-reactive leiomyosarcomas, whereas 10 of 11 positive nerve-sheath neoplasms manifested cytoplasmic staining, suggesting differences in cellularstromal interactions in these types of sarcomas. Variable patterns of reactivity in “malignant fibrous histiocytomas” appear to support an inherent heterogeneity in this class of tumors. Overall, these data indicate a wide distribution of CD44-antigen expression among soft-tissue tumors with some distinctive patterns of expression that may be useful in characterizing such neoplasms. However, CD44 staining may have only a limited role in resolving the differential diagnoses of epithelioid neoplasms.

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Jan 1, 1996

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