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RESEARCH ARTICLE CD10 (Neutral Endopeptidase) Expression in Myoepithelial Cells of Salivary Neoplasms Catarina de Oliveira Neves, MD,* Andresa Borges Soares, PhD,w Ana Fla´via Costa, DDS,* Vera Cavalcanti de Araujo, DDS, PhD,w Cristiane Furuse, DDS, PhD,w Priscila Bianchi Juliano, MD,* and Albina Altemani, MD, PhD* proteinase which controls the growth and differentiation Abstract: CD10 is a cell surface peptidase expressed in a wide in normal cells. As a cell surface peptidase, it regulates variety of normal and neoplastic tissues, including breast biologic activities of peptide substrates by reducing the myoepithelial cells. In salivary glands, expression of CD10 has local concentrations available for receptor binding and only been used to identify neoplastic myoepithelial cells of signal transduction. CD10 has been identified in a wide pleomorphic adenomas and myoepithelial carcinomas. How- variety of cell types (such as in lymphoid germinal centers, ever, its accuracy in other salivary tumors with myoepithelial renal tubules, glomeruli, hepatic parenchymal canaliculi, 3 4 component has yet to be analyzed. We examined 72 salivary syncytiotrophoblast, fibroblasts, and breast myoepithe- tumors with myoepithelial differentiation using immunohisto- lium ) and tumors (renal cell carcinoma (RCC), prostatic chemical technique to detect CD10. In salivary glands, CD10 adenocarcinoma, endometrial stromal sarcoma, rabdomyo-
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Mar 1, 2010
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