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REVIEW URRENT Cardiovascular disease risk in an aging HIV PINION population: not just a question of biology a b Kaku So-Armah and Matthew S. Freiberg Purpose of review The objective of this review is to appraise recently published literature that describes the relationship between HIV, biologic and environmental risk factors, and cardiovascular disease (CVD) risk with particular emphasis on the aging HIV population and to demonstrate that these biologic and environmental factors may interact to increase the risk of CVD in the HIV population. Recent findings The mechanisms linking HIV and CVD are multifactorial and encompass biological and ‘environmental’ modalities including multimorbid conditions that co-occur with HIV, immunologic alterations associated with HIV, polypharmacy (which affects adherence and increases likelihood of adverse drug–drug interactions) and healthcare disparities in CVD risk reduction by HIV status. Summary Data regarding optimal treatment strategies that balance immunological restoration and CVD risk reduction are needed. Keywords cardiovascular disease, clinical guidelines, healthcare disparities, HIV, multimorbidity, polypharmacy INTRODUCTION with particular emphasis on the aging HIV popu- lation; and to demonstrate that these biologic and With the success of antiretroviral therapy (ART), environmental factors may interact to increase the HIV infection has transitioned from a rapid death risk
Current Opinion in HIV and Aids – Wolters Kluwer Health
Published: Jul 1, 2014
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