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Cardiac Resynchronization Therapy and Dynamic Changes in Right Ventricular Function

Cardiac Resynchronization Therapy and Dynamic Changes in Right Ventricular Function Circulation: Cardiovascular Imaging EDITORIAL Cardiac Resynchronization Therapy and Dynamic Changes in Right Ventricular Function See Article by Martens, et al Sherif F. Nagueh, MD everal clinical trials and guidelines support the use of cardiac resynchroniza- tion therapy (CRT) in symptomatic patients with heart failure and reduced Sejection fraction (HFrEF). CRT favorably affects clinical outcomes in this pa- tient population and has been shown to result in improvement in left ventricular (LV) systolic properties. Acutely, invasive and noninvasive studies have shown atrial synchronized biventricular pacing to be accompanied by a decrease in LV dyssyn- chrony with an increase in LV contractility as inferred from the increase in LV dP/dt, thus leading to an increase in LV stroke volume. With time, LV reverse remodeling is seen with a decrease in LV volumes and an increase in LV ejection fraction (EF). The beneficial effects of CRT on LV structure and systolic function result in other favor - able changes with respect to left atrial (LA) reverse remodeling, improvement in LV diastolic function with a decrease in LV diastolic pressures and LA pressure, and a decrease in the severity of functional mitral regurgitation (MR). Importantly, each of the above changes can in turn http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Circulation: Cardiovascular Imaging Wolters Kluwer Health

Cardiac Resynchronization Therapy and Dynamic Changes in Right Ventricular Function

Nagueh, Sherif F.
Circulation: Cardiovascular Imaging , Volume 11 (9) – Sep 1, 2018
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Publisher
Wolters Kluwer Health
Copyright
© 2018 American Heart Association, Inc.
ISSN
1941-9651
eISSN
1942-0080
DOI
10.1161/CIRCIMAGING.118.008195
Publisher site
See Article on Publisher Site

Abstract

Circulation: Cardiovascular Imaging EDITORIAL Cardiac Resynchronization Therapy and Dynamic Changes in Right Ventricular Function See Article by Martens, et al Sherif F. Nagueh, MD everal clinical trials and guidelines support the use of cardiac resynchroniza- tion therapy (CRT) in symptomatic patients with heart failure and reduced Sejection fraction (HFrEF). CRT favorably affects clinical outcomes in this pa- tient population and has been shown to result in improvement in left ventricular (LV) systolic properties. Acutely, invasive and noninvasive studies have shown atrial synchronized biventricular pacing to be accompanied by a decrease in LV dyssyn- chrony with an increase in LV contractility as inferred from the increase in LV dP/dt, thus leading to an increase in LV stroke volume. With time, LV reverse remodeling is seen with a decrease in LV volumes and an increase in LV ejection fraction (EF). The beneficial effects of CRT on LV structure and systolic function result in other favor - able changes with respect to left atrial (LA) reverse remodeling, improvement in LV diastolic function with a decrease in LV diastolic pressures and LA pressure, and a decrease in the severity of functional mitral regurgitation (MR). Importantly, each of the above changes can in turn

Journal

Circulation: Cardiovascular Imaging – Wolters Kluwer Health

Published: Sep 1, 2018

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