Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Cardiac Micro–Computed Tomography Imaging of the Aging Coronary Vasculature

Cardiac Micro–Computed Tomography Imaging of the Aging Coronary Vasculature Cardiac Micro–Computed Tomography Imaging of the Aging Coronary Vasculature S. Jeson Sangaralingham, PhD; Erik L. Ritman, MD, PhD; Paul M. McKie, MD; Tomoko Ichiki, MD, PhD; Amir Lerman, MD; Christopher G. Scott, MS; Fernando L. Martin, MD; Gerald E. Harders; Diego Bellavia, MD, PhD; John C. Burnett, Jr, MD Background—Alterations at the level of the coronary circulation with aging may play an important role in the evolution of age-associated changes in left ventricular (LV) fibrosis and function. However these age-associated changes in the coronary vasculature remain poorly defined primarily due to the lack of high resolution imaging technologies. The current study was designed to utilize cardiac micro–computed tomography (micro-CT) technology as a novel imaging strategy, to define the 3-dimensional coronary circulation in the young and aged heart and its relationship to LV fibrosis and function. Methods and Results—Young (2 months old; n=10) and aged (20 months old; n=10) Fischer rats underwent cardiac micro-CT imaging as well as echocardiography, blood pressure, and fibrosis analysis. Importantly, when indexed to LV mass, which increased with age, the total and intramyocardial vessel volumes were lower, whereas the epicardial vessel volume, with and without indexing to LV mass, was significantly higher in the aged http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Circulation: Cardiovascular Imaging Wolters Kluwer Health

Cardiac Micro–Computed Tomography Imaging of the Aging Coronary Vasculature

Burnett, John C.
Circulation: Cardiovascular Imaging , Volume 5 (4) – Jul 1, 2012
Download PDF
7 pages

Loading next page...
 
/lp/wolters-kluwer-health/cardiac-micro-ndash-computed-tomography-imaging-of-the-aging-coronary-GlT08j0hCe

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Copyright
© 2012 American Heart Association, Inc.
ISSN
1941-9651
eISSN
1942-0080
DOI
10.1161/CIRCIMAGING.112.973057
pmid
22679058
Publisher site
See Article on Publisher Site

Abstract

Cardiac Micro–Computed Tomography Imaging of the Aging Coronary Vasculature S. Jeson Sangaralingham, PhD; Erik L. Ritman, MD, PhD; Paul M. McKie, MD; Tomoko Ichiki, MD, PhD; Amir Lerman, MD; Christopher G. Scott, MS; Fernando L. Martin, MD; Gerald E. Harders; Diego Bellavia, MD, PhD; John C. Burnett, Jr, MD Background—Alterations at the level of the coronary circulation with aging may play an important role in the evolution of age-associated changes in left ventricular (LV) fibrosis and function. However these age-associated changes in the coronary vasculature remain poorly defined primarily due to the lack of high resolution imaging technologies. The current study was designed to utilize cardiac micro–computed tomography (micro-CT) technology as a novel imaging strategy, to define the 3-dimensional coronary circulation in the young and aged heart and its relationship to LV fibrosis and function. Methods and Results—Young (2 months old; n=10) and aged (20 months old; n=10) Fischer rats underwent cardiac micro-CT imaging as well as echocardiography, blood pressure, and fibrosis analysis. Importantly, when indexed to LV mass, which increased with age, the total and intramyocardial vessel volumes were lower, whereas the epicardial vessel volume, with and without indexing to LV mass, was significantly higher in the aged

Journal

Circulation: Cardiovascular Imaging – Wolters Kluwer Health

Published: Jul 1, 2012

There are no references for this article.