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Cardiac Magnetic Resonance Parameters Predict Transplantation-Free Survival in Patients With Fontan Circulation

Cardiac Magnetic Resonance Parameters Predict Transplantation-Free Survival in Patients With... Congenital Heart Disease Cardiac Magnetic Resonance Parameters Predict Transplantation-Free Survival in Patients With Fontan Circulation Rahul H. Rathod, MD; Ashwin Prakash, MD; Yuli Y. Kim, MD; Ioannis E. Germanakis, MD; Andrew J. Powell, MD; Kimberlee Gauvreau, ScD; Tal Geva, MD Background—Several clinical risk factors for death and heart transplantation have been identified in patients with Fontan circulation. It is unknown whether cardiac magnetic resonance (CMR) measurements of ventricular size and function are independently associated with these outcomes and further improve risk stratification. Methods and Results—Data on patients with Fontan circulation who had a CMR study from January 2002 to January 2011 were retrospectively reviewed. The end point was time to death or listing for heart transplantation after the CMR study. The median age of the 215 patients was 18.3 years (25th, 75th percentiles: 14, 26) with a median age at Fontan of 3.6 years (2.3, 7.1). During a median post-CMR follow-up period of 4.1 years (2.6, 6.2), 24 patients (11%) reached the end point: 20 deaths, 3 transplantations, and 1 transplantation listing. In a multivariable Cox regression model with clinical parameters only, protein-losing enteropathy was associated with transplantation-free survival. A multivariable model, including clinical and CMR parameters, showed that http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Circulation: Cardiovascular Imaging Wolters Kluwer Health

Cardiac Magnetic Resonance Parameters Predict Transplantation-Free Survival in Patients With Fontan Circulation

Circulation: Cardiovascular Imaging , Volume 7 (3) – May 1, 2014

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References (26)

Copyright
© 2014 American Heart Association, Inc.
ISSN
1941-9651
eISSN
1942-0080
DOI
10.1161/CIRCIMAGING.113.001473
pmid
24619103
Publisher site
See Article on Publisher Site

Abstract

Congenital Heart Disease Cardiac Magnetic Resonance Parameters Predict Transplantation-Free Survival in Patients With Fontan Circulation Rahul H. Rathod, MD; Ashwin Prakash, MD; Yuli Y. Kim, MD; Ioannis E. Germanakis, MD; Andrew J. Powell, MD; Kimberlee Gauvreau, ScD; Tal Geva, MD Background—Several clinical risk factors for death and heart transplantation have been identified in patients with Fontan circulation. It is unknown whether cardiac magnetic resonance (CMR) measurements of ventricular size and function are independently associated with these outcomes and further improve risk stratification. Methods and Results—Data on patients with Fontan circulation who had a CMR study from January 2002 to January 2011 were retrospectively reviewed. The end point was time to death or listing for heart transplantation after the CMR study. The median age of the 215 patients was 18.3 years (25th, 75th percentiles: 14, 26) with a median age at Fontan of 3.6 years (2.3, 7.1). During a median post-CMR follow-up period of 4.1 years (2.6, 6.2), 24 patients (11%) reached the end point: 20 deaths, 3 transplantations, and 1 transplantation listing. In a multivariable Cox regression model with clinical parameters only, protein-losing enteropathy was associated with transplantation-free survival. A multivariable model, including clinical and CMR parameters, showed that

Journal

Circulation: Cardiovascular ImagingWolters Kluwer Health

Published: May 1, 2014

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