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Can We Tell the Site of Origin of Metastatic Squamous Cell Carcinoma? An Immunohistochemical Tissue Microarray Study of 194 Cases

Can We Tell the Site of Origin of Metastatic Squamous Cell Carcinoma? An... RESEARCH ARTICLE Can We Tell the Site of Origin of Metastatic Squamous Cell Carcinoma? An Immunohistochemical Tissue Microarray Study of 194 Cases Telma C. Pereira, MD,*w Sarah M. Share, MD,*w Albino V. Magalha˜es, MD, PhD,*w and Jan F. Silverman, MD*w There are many IHC markers that are relatively site- Abstract: To the workup of metastatic squamous cell carcinoma specific for a variety of adenocarcinomas and other (SCC) of unknown primary, we studied an immunohistochem- carcinomas of different organs. We reviewed the literature ical panel including thyroid transcription factor (TTF-1), napsin looking for site-specific markers that could be helpful in A, villin, CDX-2, K903, CK5/6, p63, p16, CK7, and CK20. cases of SCC, but the literature is scanty regarding the Using tissue microarray, we compared 194 SCC cases from the IHC workup of SCC of unknown primary. following sites: 35 lung, 34 skin, 14 cervix, 4 vagina, 16 vulva, 8 We chose markers that have been used for a lung penis, 9 anus, 3 rectum, 10 esophagus, 4 bladder/urethra, and 57 primary site [thyroid transcription factor (TTF-1) and SCC from various head and neck sites. p63 and K903 stained napsin A], and gastrointestinal tract primary site (CDX-2 positively in 100% http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Can We Tell the Site of Origin of Metastatic Squamous Cell Carcinoma? An Immunohistochemical Tissue Microarray Study of 194 Cases

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Copyright
Copyright #x00A9; 2010 by Lippincott Williams & Wilkins
ISSN
1541-2016
DOI
10.1097/PAI.0b013e3181ecaf1c
pmid
20823766
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Can We Tell the Site of Origin of Metastatic Squamous Cell Carcinoma? An Immunohistochemical Tissue Microarray Study of 194 Cases Telma C. Pereira, MD,*w Sarah M. Share, MD,*w Albino V. Magalha˜es, MD, PhD,*w and Jan F. Silverman, MD*w There are many IHC markers that are relatively site- Abstract: To the workup of metastatic squamous cell carcinoma specific for a variety of adenocarcinomas and other (SCC) of unknown primary, we studied an immunohistochem- carcinomas of different organs. We reviewed the literature ical panel including thyroid transcription factor (TTF-1), napsin looking for site-specific markers that could be helpful in A, villin, CDX-2, K903, CK5/6, p63, p16, CK7, and CK20. cases of SCC, but the literature is scanty regarding the Using tissue microarray, we compared 194 SCC cases from the IHC workup of SCC of unknown primary. following sites: 35 lung, 34 skin, 14 cervix, 4 vagina, 16 vulva, 8 We chose markers that have been used for a lung penis, 9 anus, 3 rectum, 10 esophagus, 4 bladder/urethra, and 57 primary site [thyroid transcription factor (TTF-1) and SCC from various head and neck sites. p63 and K903 stained napsin A], and gastrointestinal tract primary site (CDX-2 positively in 100%

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Jan 1, 2011

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