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Bullous Pemphigoid

Bullous Pemphigoid Bullous pemphigoid is the most common autoimmune bullous skin disease and primarily affects patients older than 60 years. This chronic disease can lead to significant morbidity characterized by spontaneous remissions and exacerbations. Although the etiopathogenesis is uncertain, it is proposed that certain drugs (especially polypharmacy), vaccinations, infections, and exposures precede the dermatological presentation. Bullous pemphigoid patients initially present with moderate-to-severe pruritis with or without eczematous or urticarial lesions, followed by the development of cutaneous bullae weeks to months later testing with a notable false-positive Nikolsky sign. As frontline providers, emergency department nurse practitioners should be aware of these skin diseases in the elderly. Prompt recognition of bullous pemphigoid leads to an earlier diagnosis and management of this common autoimmune bullous skin disease and requires clinicians to have critical observation skills. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Advanced Emergency Nursing Journal Wolters Kluwer Health

Bullous Pemphigoid

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Publisher
Wolters Kluwer Health
Copyright
© 2021 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
1931-4485
eISSN
1931-4493
DOI
10.1097/tme.0000000000000372
Publisher site
See Article on Publisher Site

Abstract

Bullous pemphigoid is the most common autoimmune bullous skin disease and primarily affects patients older than 60 years. This chronic disease can lead to significant morbidity characterized by spontaneous remissions and exacerbations. Although the etiopathogenesis is uncertain, it is proposed that certain drugs (especially polypharmacy), vaccinations, infections, and exposures precede the dermatological presentation. Bullous pemphigoid patients initially present with moderate-to-severe pruritis with or without eczematous or urticarial lesions, followed by the development of cutaneous bullae weeks to months later testing with a notable false-positive Nikolsky sign. As frontline providers, emergency department nurse practitioners should be aware of these skin diseases in the elderly. Prompt recognition of bullous pemphigoid leads to an earlier diagnosis and management of this common autoimmune bullous skin disease and requires clinicians to have critical observation skills.

Journal

Advanced Emergency Nursing Journal – Wolters Kluwer Health

Published: Oct 1, 2021

References

  • Bullous pemphigoid
  • Bullous pemphigoid: A review of its diagnosis, associations and treatment
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  • Desquamative gingivitis—a clinical sign in mucous membrane pemphigoid: Report of a case and review of literature
  • Pathophysiologic mechanisms of itch in bullous pemphigoid
  • Clinical features and diagnosis of bullous pemphigoid and mucous membrane pemphigoid
  • Association between medication use and bullous pemphigoid: A systematic review and meta-analysis
  • A case of nivolumab-induced bullous pemphigoid: Review of dermatologic toxicity associated with programmed cell death protein-1/programmed death ligand-1 inhibitors and recommendations for diagnosis and management
  • Pharmacological advances in pemphigoid
  • Nikolsky's sign: A pathognomic boon
  • Bullous pemphigoid: Trigger and predisposing factors
  • Resolution in bullous pemphigoid
  • Bullous pemphigoid in infants: Characteristics, diagnosis and treatment
  • A systematic review of drug-induced pemphigoid