Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Broadly neutralizing antibody and the HIV reservoir in acute HIV infection a strategy toward HIV remission?

Broadly neutralizing antibody and the HIV reservoir in acute HIV infection a strategy toward HIV... REVIEW URRENT Broadly neutralizing antibody and the HIV reservoir PINION in acute HIV infection: a strategy toward HIV remission? a,b a,b a,b Jintanat Ananworanich , Brian McSteen , and Merlin L. Robb Purpose of review Infection of long-lived CD4 T cells is a major obstacle to HIV remission, and antiretroviral therapy (ART) instituted during acute HIV infection restricts HIV reservoir establishment. Broadly neutralizing antibodies (bNAbs) may be employed in conjunction with early ART as strategies toward HIV remission. Recent findings Proof-of-concept studies in vitro and in animal models demonstrated bNAbs’ ability to block viral entry into cells, suppress viremia and reduce cell-associated viral DNA. Combination bNAbs were more effective than single bNAb in suppressing viremia. When bNAb was used with ART with or without combination latency reversing agents, it prevented viral rebound after ART interruption in at least half of the animals. In one study, macaques with low baseline viral load achieved viral remission even after the blood bNAb titer was no longer detected. Summary The acute HIV infection period represents a unique opportunity to explore the use of bNAbs with ART to limit the reservoir seeding that may enhance the chance of HIV remission. This article discusses the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and Aids Wolters Kluwer Health

Broadly neutralizing antibody and the HIV reservoir in acute HIV infection a strategy toward HIV remission?

Current Opinion in HIV and Aids , Volume 10 (3) – May 1, 2015

Loading next page...
 
/lp/wolters-kluwer-health/broadly-neutralizing-antibody-and-the-hiv-reservoir-in-acute-hiv-tJ66RoIrN0

References (40)

Copyright
Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
1746-630X
eISSN
1746-6318
DOI
10.1097/COH.0000000000000144
pmid
25700203
Publisher site
See Article on Publisher Site

Abstract

REVIEW URRENT Broadly neutralizing antibody and the HIV reservoir PINION in acute HIV infection: a strategy toward HIV remission? a,b a,b a,b Jintanat Ananworanich , Brian McSteen , and Merlin L. Robb Purpose of review Infection of long-lived CD4 T cells is a major obstacle to HIV remission, and antiretroviral therapy (ART) instituted during acute HIV infection restricts HIV reservoir establishment. Broadly neutralizing antibodies (bNAbs) may be employed in conjunction with early ART as strategies toward HIV remission. Recent findings Proof-of-concept studies in vitro and in animal models demonstrated bNAbs’ ability to block viral entry into cells, suppress viremia and reduce cell-associated viral DNA. Combination bNAbs were more effective than single bNAb in suppressing viremia. When bNAb was used with ART with or without combination latency reversing agents, it prevented viral rebound after ART interruption in at least half of the animals. In one study, macaques with low baseline viral load achieved viral remission even after the blood bNAb titer was no longer detected. Summary The acute HIV infection period represents a unique opportunity to explore the use of bNAbs with ART to limit the reservoir seeding that may enhance the chance of HIV remission. This article discusses the

Journal

Current Opinion in HIV and AidsWolters Kluwer Health

Published: May 1, 2015

There are no references for this article.