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BRMS1 and HPA as Progression, Clinical Biological Behaviors, and Poor Prognosis–related Biomarkers for Gallbladder Adenocarcinoma

BRMS1 and HPA as Progression, Clinical Biological Behaviors, and Poor Prognosis–related... Purpose: To study the expression of breast cancer metastasis suppressor 1 (BRMS1) and heparanase (HPA) and evaluate their clinicopathologic significance and relationship in benign and malignant lesions of the gallbladder. Materials and Methods: EnVision immunohistochemical method for determining the expression of BRMS1 and HPA was used in routinely paraffin-embedded sections of surgical resected specimens from gallbladder adenocarcinoma, peritumoral tissues, polyp, and chronic cholecystitis. Results: The positive rate of BRMS1 expression was significantly lower in gallbladder adenocarcinoma than that in peritumoral tissues ( P <0.01), polyp ( P <0.01), and chronic cholecystitis ( P <0.01). The positive rate of HPA expression was significantly higher in gallbladder adenocarcinoma than that in peritumoral tissues ( P <0.01), polyp ( P <0.05), and chronic cholecystitis ( P <0.01). The positive expression of BRMS1 and negative expression of HPA were significantly associated with differentiation, lymph node metastasis, and invasion of adenocarcinoma ( P <0.05 or P <0.01). Unitivariate Kaplan-Meier analysis showed that decreased expression of BRMS1 ( P =0.008) or increased expression of HPA ( P =0.016) was associated with decreased overall survival. Multivariate Cox regression analysis showed that decreased expression of BRMS1 ( P =0.011) and/or increased expression of HPA ( P =0.019) was an independent bad prognostic predictor in gallbladder adenocarcinoma. Conclusion: The expression of BRMS1 and/or HPA might be closely related to the carcinogenesis, clinical biological behaviors, and prognosis of gallbladder adenocarcinoma. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

BRMS1 and HPA as Progression, Clinical Biological Behaviors, and Poor Prognosis–related Biomarkers for Gallbladder Adenocarcinoma

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Copyright
Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
Subject
Research Articles
ISSN
1541-2016
eISSN
1533-4058
DOI
10.1097/PAI.0000000000000183
pmid
26200836
Publisher site
See Article on Publisher Site

Abstract

Purpose: To study the expression of breast cancer metastasis suppressor 1 (BRMS1) and heparanase (HPA) and evaluate their clinicopathologic significance and relationship in benign and malignant lesions of the gallbladder. Materials and Methods: EnVision immunohistochemical method for determining the expression of BRMS1 and HPA was used in routinely paraffin-embedded sections of surgical resected specimens from gallbladder adenocarcinoma, peritumoral tissues, polyp, and chronic cholecystitis. Results: The positive rate of BRMS1 expression was significantly lower in gallbladder adenocarcinoma than that in peritumoral tissues ( P <0.01), polyp ( P <0.01), and chronic cholecystitis ( P <0.01). The positive rate of HPA expression was significantly higher in gallbladder adenocarcinoma than that in peritumoral tissues ( P <0.01), polyp ( P <0.05), and chronic cholecystitis ( P <0.01). The positive expression of BRMS1 and negative expression of HPA were significantly associated with differentiation, lymph node metastasis, and invasion of adenocarcinoma ( P <0.05 or P <0.01). Unitivariate Kaplan-Meier analysis showed that decreased expression of BRMS1 ( P =0.008) or increased expression of HPA ( P =0.016) was associated with decreased overall survival. Multivariate Cox regression analysis showed that decreased expression of BRMS1 ( P =0.011) and/or increased expression of HPA ( P =0.019) was an independent bad prognostic predictor in gallbladder adenocarcinoma. Conclusion: The expression of BRMS1 and/or HPA might be closely related to the carcinogenesis, clinical biological behaviors, and prognosis of gallbladder adenocarcinoma.

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Apr 1, 2016

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