Access the full text.
Sign up today, get DeepDyve free for 14 days.
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
ORIGINAL ARTICLE Brain Apparent Diffusion Coefficient Evaluation in Pediatric Patients With Neurofibromatosis Type 1 Giuseppe Tognini, MD,* Francesco Ferrozzi, MD,* Giacomo Garlaschi, MD,† Paolo Piazza, MD,‡ Arianna Patti, MD,* Raffaele Virdis, MD,§ Chiara Bertolino, MD,‡ Giancarlo Bertolino, MD,‡ Daniele Manfredini, DDS, Maurizio Zompatori, MD,* and Girolamo Crisi, MD‡ eurofibromatosis type 1 (NF1) is the most common of the Objective: The most frequent intracranial appearance in children Nphakomatoses (neurocutaneous syndromes) and occurs 1–3 with neurofibromatosis type 1 (NF1) is represented by the presence in 1 of every 2500 to 3000 live births. It is inherited in an of hyperintense lesions on T2-weighted images, the so-called autosomal dominant fashion with a high rate of penetrance, ‘‘unidentified bright objects’’ (UBOs). Di Paolo demonstrated that but approximately half of the cases represent new mutations. these lesions represent foci of myelin vacuolization with increased The NF1 gene is located on the long arm of chromosome water content. The aim of this study was to investigate the isotropic 17 and shows a high mutation rate. Such a locus encodes apparent diffusion coefficient (ADC) values within the UBOs and for neurofibromin, a 250-KDa protein with specific tumor normal-appearing brain and at the regressed UBO sites. suppressor
Journal of Computer Assisted Tomography – Wolters Kluwer Health
Published: May 1, 2005
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.