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Biology of HIV mucosal transmission

Biology of HIV mucosal transmission Li Wu Department of Microbiology and Molecular Genetics, Purpose of review Medical College of Wisconsin, Milwaukee, Wisconsin, HIV-1 mucosal transmission plays a critical role in HIV-1 infection and AIDS USA pathogenesis. This review summarizes the latest advances in biological studies of HIV-1 Correspondence to Li Wu, Department of Microbiology mucosal transmission, highlighting the implications of these studies in the development and Molecular Genetics, BSB 203, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, of microbicides to prevent HIV-1 transmission. WI 53226, USA Recent findings Tel: +1 414 456 4075; fax: +1 414 456 6535; e-mail: liwu@mcw.edu New studies of initial HIV-1 infection using improved culture models updated the current view of mucosal transmission. Mechanistic studies enhanced our understanding of cell – cell transmission of HIV-1 mediated by the major target cells, including dendritic Current Opinion in HIV and AIDS 2008, 3:534– cells, CD4 T cells, and macrophages. Increasing evidence indicated the significance of host factors and immune responses in HIV-1 mucosal infection and transmission. Summary Recent progress in HIV-1 mucosal infection and transmission enriches our knowledge of virus – host interactions and viral pathogenesis. Functional studies of HIV-1 interactions with host cells can provide new insights into the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and Aids Wolters Kluwer Health

Biology of HIV mucosal transmission

Current Opinion in HIV and Aids , Volume 3 (5) – Sep 1, 2008

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ISSN
1746-630X
eISSN
1746-6318
DOI
10.1097/COH.0b013e32830634c6
pmid
18802490
Publisher site
See Article on Publisher Site

Abstract

Li Wu Department of Microbiology and Molecular Genetics, Purpose of review Medical College of Wisconsin, Milwaukee, Wisconsin, HIV-1 mucosal transmission plays a critical role in HIV-1 infection and AIDS USA pathogenesis. This review summarizes the latest advances in biological studies of HIV-1 Correspondence to Li Wu, Department of Microbiology mucosal transmission, highlighting the implications of these studies in the development and Molecular Genetics, BSB 203, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, of microbicides to prevent HIV-1 transmission. WI 53226, USA Recent findings Tel: +1 414 456 4075; fax: +1 414 456 6535; e-mail: liwu@mcw.edu New studies of initial HIV-1 infection using improved culture models updated the current view of mucosal transmission. Mechanistic studies enhanced our understanding of cell – cell transmission of HIV-1 mediated by the major target cells, including dendritic Current Opinion in HIV and AIDS 2008, 3:534– cells, CD4 T cells, and macrophages. Increasing evidence indicated the significance of host factors and immune responses in HIV-1 mucosal infection and transmission. Summary Recent progress in HIV-1 mucosal infection and transmission enriches our knowledge of virus – host interactions and viral pathogenesis. Functional studies of HIV-1 interactions with host cells can provide new insights into the

Journal

Current Opinion in HIV and AidsWolters Kluwer Health

Published: Sep 1, 2008

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