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Beyond IL-17: new cytokines in the pathogenesis of HIV infection

Beyond IL-17: new cytokines in the pathogenesis of HIV infection Beyond IL-17: new cytokines in the pathogenesis of HIV infection a,b Mario Clerici Chair of Immunology, Department of Biomedical Purpose of the review Sciences and Technologies, University of Milano and Alterations in cytokine production have been described since the dawn of HIV research. Don C. Gnocchi ONLUS Foundation IRCCS, Milan, Italy Cytokinology is rapidly evolving because the cytokine-like functions of arrays of proteins are being recognized. Thus, new cytokines are being investigated within the context of Correspondence to Professor Mario Clerici, MD, Chair of Immunology, Department of Biomedical Sciences HIV pathogenesis. This review describes novel functions of ‘old’ cytokines and and Technologies, University of Milano. Via Fratelli summarizes the potential role of ‘new’ cytokines in this disease. Cervi 93, 20090 Segrate, Milan, Italy Tel: +39 02 50330412; fax: +39 02 50330413; Recent findings e-mail: mario.clerici@unimi.it Old cytokines, such as the common gamma (g) chain cytokines, were shown to have Current Opinion in HIV and AIDS 2010, previously unsuspected biological roles; new cytokines, for example, IL-18, IL-27, IL-32, 5:184–188 were recognized as important players in the immunopathogenesis of HIV infection. Finally, hepatocytes were demonstrated to be the main producers of IL-7 in response to various inflammatory signals, transforming overnight the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in HIV and Aids Wolters Kluwer Health

Beyond IL-17: new cytokines in the pathogenesis of HIV infection

Clerici, Mario
Current Opinion in HIV and Aids , Volume 5 (2) – Mar 1, 2010
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References (57)

ISSN
1746-630X
eISSN
1746-6318
DOI
10.1097/COH.0b013e328335c23c
pmid
20543598
Publisher site
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Abstract

Beyond IL-17: new cytokines in the pathogenesis of HIV infection a,b Mario Clerici Chair of Immunology, Department of Biomedical Purpose of the review Sciences and Technologies, University of Milano and Alterations in cytokine production have been described since the dawn of HIV research. Don C. Gnocchi ONLUS Foundation IRCCS, Milan, Italy Cytokinology is rapidly evolving because the cytokine-like functions of arrays of proteins are being recognized. Thus, new cytokines are being investigated within the context of Correspondence to Professor Mario Clerici, MD, Chair of Immunology, Department of Biomedical Sciences HIV pathogenesis. This review describes novel functions of ‘old’ cytokines and and Technologies, University of Milano. Via Fratelli summarizes the potential role of ‘new’ cytokines in this disease. Cervi 93, 20090 Segrate, Milan, Italy Tel: +39 02 50330412; fax: +39 02 50330413; Recent findings e-mail: mario.clerici@unimi.it Old cytokines, such as the common gamma (g) chain cytokines, were shown to have Current Opinion in HIV and AIDS 2010, previously unsuspected biological roles; new cytokines, for example, IL-18, IL-27, IL-32, 5:184–188 were recognized as important players in the immunopathogenesis of HIV infection. Finally, hepatocytes were demonstrated to be the main producers of IL-7 in response to various inflammatory signals, transforming overnight the

Journal

Current Opinion in HIV and Aids – Wolters Kluwer Health

Published: Mar 1, 2010

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