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Basal Lamina Visualization Using Color Image Processing and Pattern Recognition

Basal Lamina Visualization Using Color Image Processing and Pattern Recognition TECHNICAL Basal Lamina Visualization Using Color Image Processing and Pattern Recognition F. Joel W.-M. Leong, MD, PhD (Oxon),* Anthony S.-Y. Leong, MB, MD, FRCPA, FRCPath, FCAP, FASCP, FHKAM (Pathol), Hon FHKCPath, Hon FRCPath (Thailand),† Michael Brady, FRS, FREng, FIEE, FInstP, FAAAI,‡ and James O’D. McGee, MD, PhD, FRCPG, MA, FMedSci§ tent. It also contains non-collagenous glycoproteins such as Abstract: In histologic assessment, the absence of basal lamina is laminin, fibronectin, heparin sulfate, proteoglycan, entactin, a useful feature for distinguishing invasive malignancy from benign This barrier of fibronectin, and other glycosaminoglycans. and in situ lesions. As this feature is not possible to assess in routine granulofilamentous polysaccharide-rich material with associ- H&E sections, pathologists have instead relied on histochemical and ated collagen fibrils is present at the base of epithelium and immunohistochemical stains to show components of the basal lam- around benign glands but is generally absent around the ma- ina such as laminin or type IV collagen. Standard image-processing lignant glands of invasive carcinoma. The basal lamina has software with the necessary image-processing toolbox (Matlab v5, been examined in isolation, on the basis that it forms a sig- Mathworks, Natick, MA) was used in a unique combination of color nificant http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Basal Lamina Visualization Using Color Image Processing and Pattern Recognition

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References (13)

Copyright
Copyright © 2005 by Lippincott Williams & Wilkins
ISSN
1541-2016
DOI
10.1097/01.pai.0000159951.72121.27
Publisher site
See Article on Publisher Site

Abstract

TECHNICAL Basal Lamina Visualization Using Color Image Processing and Pattern Recognition F. Joel W.-M. Leong, MD, PhD (Oxon),* Anthony S.-Y. Leong, MB, MD, FRCPA, FRCPath, FCAP, FASCP, FHKAM (Pathol), Hon FHKCPath, Hon FRCPath (Thailand),† Michael Brady, FRS, FREng, FIEE, FInstP, FAAAI,‡ and James O’D. McGee, MD, PhD, FRCPG, MA, FMedSci§ tent. It also contains non-collagenous glycoproteins such as Abstract: In histologic assessment, the absence of basal lamina is laminin, fibronectin, heparin sulfate, proteoglycan, entactin, a useful feature for distinguishing invasive malignancy from benign This barrier of fibronectin, and other glycosaminoglycans. and in situ lesions. As this feature is not possible to assess in routine granulofilamentous polysaccharide-rich material with associ- H&E sections, pathologists have instead relied on histochemical and ated collagen fibrils is present at the base of epithelium and immunohistochemical stains to show components of the basal lam- around benign glands but is generally absent around the ma- ina such as laminin or type IV collagen. Standard image-processing lignant glands of invasive carcinoma. The basal lamina has software with the necessary image-processing toolbox (Matlab v5, been examined in isolation, on the basis that it forms a sig- Mathworks, Natick, MA) was used in a unique combination of color nificant

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Sep 1, 2005

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