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Atypical Pituitary Adenoma With Neurocytic Transformation

Atypical Pituitary Adenoma With Neurocytic Transformation CASE REPORT Atypical Pituitary Adenoma With Neurocytic Transformation Fabio Rotondo, BSc,* Marie Christine F. Bernardo, MD,w Bernd W. Scheithauer, MD{,w Shahnila Latif, MD,z Christopher Bogaev, MD,y Aydin Sav, MD,8 and Kalman Kovacs, MD, PhD* More recently described were 2 lesions termed Abstract: Here, we report an example of an atypical prolactin- “pituitary adenoma with incomplete neuronal trans- producing pituitary adenoma showing clear morphologic and 11,12 formation.” One, a functional corticotroph adenoma, immunohistochemical evidence of neurocytic transformation. was characterized by small, hybrid adenoma-neuronal Its features support the concept that neoplastic neuroendocrine cells, the only characteristics of that latter being ultra- cells, in this case adenohypophyseal cells, are capable of neu- 12 structurally apparent. The other was a lactotroph ad- ronal differentiation and broaden the morphologic spectrum of enoma featuring multiple intercellular foci of neuropil. such rare tumors. Our findings have implications with respect to Here, we described yet another distinctive tumor featur- the nosology of neuronal tumors of the adenohypophysis. ing both adenoma cells and differentiated, albeit non- ganglionic neurons resembling neurocytes. Nosologically, Key Words: neurocytic transformation, pituitary adenoma, such tumors occupy a unique position in the spectrum of prolactin, immunohistochemistry adenohypophyseal tumors with neuronal features. (Appl Immunohistochem Mol Morphol http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Atypical Pituitary Adenoma With Neurocytic Transformation

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Copyright
Copyright © 2013 by Lippincott Williams & Wilkins
ISSN
1541-2016
DOI
10.1097/PAI.0b013e3182634969
pmid
22914612
Publisher site
See Article on Publisher Site

Abstract

CASE REPORT Atypical Pituitary Adenoma With Neurocytic Transformation Fabio Rotondo, BSc,* Marie Christine F. Bernardo, MD,w Bernd W. Scheithauer, MD{,w Shahnila Latif, MD,z Christopher Bogaev, MD,y Aydin Sav, MD,8 and Kalman Kovacs, MD, PhD* More recently described were 2 lesions termed Abstract: Here, we report an example of an atypical prolactin- “pituitary adenoma with incomplete neuronal trans- producing pituitary adenoma showing clear morphologic and 11,12 formation.” One, a functional corticotroph adenoma, immunohistochemical evidence of neurocytic transformation. was characterized by small, hybrid adenoma-neuronal Its features support the concept that neoplastic neuroendocrine cells, the only characteristics of that latter being ultra- cells, in this case adenohypophyseal cells, are capable of neu- 12 structurally apparent. The other was a lactotroph ad- ronal differentiation and broaden the morphologic spectrum of enoma featuring multiple intercellular foci of neuropil. such rare tumors. Our findings have implications with respect to Here, we described yet another distinctive tumor featur- the nosology of neuronal tumors of the adenohypophysis. ing both adenoma cells and differentiated, albeit non- ganglionic neurons resembling neurocytes. Nosologically, Key Words: neurocytic transformation, pituitary adenoma, such tumors occupy a unique position in the spectrum of prolactin, immunohistochemistry adenohypophyseal tumors with neuronal features. (Appl Immunohistochem Mol Morphol

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Jan 1, 2014

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