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ORIGINAL ARTICLE Association of Cytidine Deaminase and Xeroderma Pigmentosum Group D Polymorphisms with Response, Toxicity, and Survival in Cisplatin/Gemcitabine-Treated Advanced Non-small Cell Lung Cancer Patients Vienna Ludovini, PhD,* Irene Floriani, PhD,† Lorenza Pistola, PhD,* Vincenzo Minotti, MD,* Marialuisa Meacci, MD,* Rita Chiari, MD,* Daniela Garavaglia, MSc,† Francesca Romana Tofanetti, PhD,* Antonella Flacco, PhD,* Annamaria Siggillino, PhD,* Elisa Baldelli, PhD,* Maurizio Tonato, MD,‡ and Lucio Crino`, MD* he combination of two cytotoxic drugs, a platinum and Background: Selecting patients according to key genetic character- Tnonplatinum agent, is the standard of care for first-line istics may help to tailor chemotherapy and optimize the treatment in treatment of patients with advanced non-small cell lung non-small cell lung cancer (NSCLC). Genetic variations in drug me- cancer (NSCLC) and good performance status (PS, 0 to 1). tabolism may affect the clinical response, toxicity, and prognosis of In an attempt to improve activity and efficacy of current NSCLC patients treated with cisplatin/gemcitabine-based therapy. regimens, a pharmacogenetic approach has been advocated. Patients and Methods: We evaluated seven single-nucleotide poly- Pharmacogenetics may reduce the variation in how individual morphisms of six genes CDA Lys27Gln (A/C); CDA C435T; patients respond to medicines by tailoring therapies to their ERCC1
Journal of Thoracic Oncology – Wolters Kluwer Health
Published: Dec 1, 2011
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