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Assessment of Liver and Spleen Stiffness in Patients With Myelofibrosis Using FibroScan and Shear Wave Elastography

Assessment of Liver and Spleen Stiffness in Patients With Myelofibrosis Using FibroScan and Shear... Downloaded from http://journals.lww.com/ultrasound-quarterly by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/03/2020 ORIGINAL RESEARCH Assessment of Liver and Spleen Stiffness in Patients With Myelofibrosis Using FibroScan and Shear Wave Elastography Muriel Webb, MD,*Þ Oren Shibolet, MD,*Þ Zamir Halpern, MD,*Þ Meital Nagar, PhD,þ Ninette Amariglio, PhD,þ Stella Levit, BS,*Þ David M. Steinberg, PhD,§ Erwin Santo, MD,*Þ and Ophira Salomon, MDÞ|| hiladelphia chromosome-negative myeloproliferative neo- Abstract: Liver stiffness and spleen stiffness in patients with mye- Pplasms include polycythemia vera (PV), essential throm- lofibrosis have traditionally been assessed through manual palpation bocythemia (ET), and primary myelofibrosis. Polycythemia and thus influenced by interobserver variability. In this article, for the vera, ET, and primary myelofibrosis are stem cellYderived first time, liver stiffness and spleen stiffness of patients with myelofibrosis monoclonal hematopoietic disorders giving rise to uncontrolled were evaluated through FibroScan and shear wave elastography (SWE). expansion of 1 or more myeloid lineages. The initiating genetic Nine patients with myelofibrosis comprised the study group. event leading to myeloproliferative disorder is still unknown; They were compared with 11 patients with liver cirrhosis and however, 96% of patients with PV harbor the somatic mutation in 8 healthy volunteers. Before the FibroScan study, all patients underwent the Janus kinase 2 (JAK2) gene, the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Ultrasound quarterly Wolters Kluwer Health

Assessment of Liver and Spleen Stiffness in Patients With Myelofibrosis Using FibroScan and Shear Wave Elastography

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References (22)

Publisher
Wolters Kluwer Health
ISSN
0894-8771
eISSN
1536-0253
DOI
10.1097/RUQ.0000000000000139
Publisher site
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Abstract

Downloaded from http://journals.lww.com/ultrasound-quarterly by BhDMf5ePHKbH4TTImqenVA5KvPVPZ0P5BEgU+IUTEfzO/GUWifn2IfwcEVVH9SSn on 06/03/2020 ORIGINAL RESEARCH Assessment of Liver and Spleen Stiffness in Patients With Myelofibrosis Using FibroScan and Shear Wave Elastography Muriel Webb, MD,*Þ Oren Shibolet, MD,*Þ Zamir Halpern, MD,*Þ Meital Nagar, PhD,þ Ninette Amariglio, PhD,þ Stella Levit, BS,*Þ David M. Steinberg, PhD,§ Erwin Santo, MD,*Þ and Ophira Salomon, MDÞ|| hiladelphia chromosome-negative myeloproliferative neo- Abstract: Liver stiffness and spleen stiffness in patients with mye- Pplasms include polycythemia vera (PV), essential throm- lofibrosis have traditionally been assessed through manual palpation bocythemia (ET), and primary myelofibrosis. Polycythemia and thus influenced by interobserver variability. In this article, for the vera, ET, and primary myelofibrosis are stem cellYderived first time, liver stiffness and spleen stiffness of patients with myelofibrosis monoclonal hematopoietic disorders giving rise to uncontrolled were evaluated through FibroScan and shear wave elastography (SWE). expansion of 1 or more myeloid lineages. The initiating genetic Nine patients with myelofibrosis comprised the study group. event leading to myeloproliferative disorder is still unknown; They were compared with 11 patients with liver cirrhosis and however, 96% of patients with PV harbor the somatic mutation in 8 healthy volunteers. Before the FibroScan study, all patients underwent the Janus kinase 2 (JAK2) gene, the

Journal

Ultrasound quarterly – Wolters Kluwer Health

Published: Sep 1, 2015

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