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RESEARCH ARTICLE Assessment of Human Epidermal Growth Factor Receptor 2 Status in Urothelial Carcinoma of the Upper Urinary Tract: A Study Using Dual-color In Situ Hybridization and Immunohistochemistry Marie Vershasselt-Crinquette, MD,* Pierre Colin, MD,w Adil Ouzzane, MD,w Viviane Gnemmi, MD,* Yves-Marie Robin, MD,z Sebastien Aubert, MD, PhD,* Arnauld Villers, MD, PhD,w and Xavier Leroy, MD, PhD* pper urinary tract urothelial carcinoma (UUTUC) is Aim: Upper urinary tract urothelial carcinoma (UUTUC) is an Ua rare adult malignant neoplasm. UUTUCs present uncommon neoplasm frequently discovered at a high-stage many similarities with tumors of the bladder but are disease. The prognosis of disseminated UUTUCs is poor despite characterized by a less favorable prognosis in relation 1–3 the use of platinum-based chemotherapy. The aim of the study with a late diagnosis. UUTUCs are also remarkable was to evaluate HER2 overexpression and amplification in a because these tumors belong to the spectrum of Lynch series of 83 UUTUCs. syndrome. The prognosis of high-grade and high-stage tumors is poor despite the use of platinum-based che- Materials and Methods: All tumors were formalin fixed. TNM motherapy. Anti-HER2 therapy is well established in stage, grade, lymphovascular invasion, surgical margins, mor- breast carcinoma with overexpression/amplification of phologic variants
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Jul 1, 2012
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