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EDITORIAL COMMENT Applications of flow cytometry for the study of primary immune deficiencies a b a Joao B. Oliveira , Luigi D. Notarangelo and Thomas A. Fleisher Immunology Service, Department of Laboratory Purpose of review Medicine, National Institutes of Health, Bethesda, b This review focuses on the current applications of flow cytometry for the diagnosis and Maryland and Division of Immunology, Children’s Hospital, Harvard Medical School, Boston, evaluation of primary immune deficiencies (PIDs). Massachusetts, USA Recent findings Correspondence to Thomas A. Fleisher, MD, The immunophenotypic evaluation of selected PIDs provides diagnostic clues as well as Immunology Service, Department of Laboratory information useful to classify patients and predict clinical outcome. In addition, the Medicine, Clinical Center, National Institutes of Health, Bldg. 10, Room 2C306, 10 Center Drive, MSC 1508, evaluation of intracellular proteins associated with selected PIDs has evolved as a useful Bethesda, MD 20892-1508, USA diagnostic screening method. Finally, functional flow cytometry can now help to clarify Tel: +1 301 496 5668; e-mail: tfleishe@mail.nih.gov possible sites of genetic defects associated with specific PIDs. Current Opinion in Allergy and Clinical Summary Immunology 2008, 8:499 – 509 The range of PIDs in which flow cytometry has proven to be useful from
Current Opinion in Allergy and Clinical Immunology – Wolters Kluwer Health
Published: Dec 1, 2008
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