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TECHNICAL ARTICLE Application of Two Different Clones of Vimentin to the Diagnosis of Salivary Gland Tumors Cristiane Furuse, DDS, PhD,* Patrıcia Ramos Cury, DDS, PhD,* Ney Soares de Arau´jo, DDS, PhD,w and Vera Cavalcanti de Arau´jo, DDS, PhD* duct carcinoma, acinic cell carcinoma, canalicular ade- 7–9 Abstract: With the evolution of IHC techniques, a broad range noma, cystadenomas, and papillomas. Therefore, it is of antibodies have become available to diagnostic immunohisto- very important in distinguishing among tumors of logy. The authors observed different expressions of vimentin in salivary gland origin. salivary gland tumors using two clones of this antibody. This With the evolution of IHC techniques, a broad study was undertaken to show these differences comparing the range of antibodies have become available to diagnostic immunoexpression of two clones of vimentin (V9 and Vim 3B4, immunohistology. There is also, as stated by Leong, ‘‘an DAKO, Carpenteria, CA) using 10 pleomorphic adenomas, 10 increasing choice of antibodies that are purported to adenoid cystic carcinomas, and 4 epithelial/myoepithelial detect the same antigen but, in fact detect different carcinomas of the salivary glands. The V9 clone of vimentin epitopes, albeit of the same antigen.’’ In our laboratory, was much more efficient in
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Jun 1, 2006
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