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Application of HER2

Application of HER2 RESEARCH ARTICLE Application of HER2 CISH pharmDX for DNA Ploidy Determination Mai He, MD, PhD,*w Terese Pasquariello, BS,* and Margaret Steinhoff, MD*w ward. For example, villous edema is a major feature of Abstract: Products of conception (POC) are encountered daily in molar POC. However, different degree of hydropic general pathology practice. The molar workup is an important changes can be seen in nonmolar POC, partial hydatidi- part of POC examination. Ploidy analysis, expressed as DNA form mole (PM), and complete hydatidifom mole (CM). index (DI), is part of the pathologic workup of molar preg- Ploidy analysis, expressed as DNA index (DI), is part nancy. For the past decade, chromogenic in situ hybridization of the pathologic workup of molar pregnancy. DI can be (CISH) has become a popular way to detect HER2 gene am- assessed by means such as flow cytometry (FC) measure- plification. Current study aims to determine whether HER2 ment of DNA content at different phases of cell cycle, by CISH dual-color assay can be used to determine DI in POCs. interphase fluorescence in situ hybridization, or by cyto- Twenty-two POC cases were chosen from the departmental ar- genetics. These techniques require specific equipment other chives, including 6 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

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Copyright
Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
1541-2016
DOI
10.1097/PAI.0000000000000220
pmid
26317311
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Application of HER2 CISH pharmDX for DNA Ploidy Determination Mai He, MD, PhD,*w Terese Pasquariello, BS,* and Margaret Steinhoff, MD*w ward. For example, villous edema is a major feature of Abstract: Products of conception (POC) are encountered daily in molar POC. However, different degree of hydropic general pathology practice. The molar workup is an important changes can be seen in nonmolar POC, partial hydatidi- part of POC examination. Ploidy analysis, expressed as DNA form mole (PM), and complete hydatidifom mole (CM). index (DI), is part of the pathologic workup of molar preg- Ploidy analysis, expressed as DNA index (DI), is part nancy. For the past decade, chromogenic in situ hybridization of the pathologic workup of molar pregnancy. DI can be (CISH) has become a popular way to detect HER2 gene am- assessed by means such as flow cytometry (FC) measure- plification. Current study aims to determine whether HER2 ment of DNA content at different phases of cell cycle, by CISH dual-color assay can be used to determine DI in POCs. interphase fluorescence in situ hybridization, or by cyto- Twenty-two POC cases were chosen from the departmental ar- genetics. These techniques require specific equipment other chives, including 6

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Aug 1, 2015

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