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Antiatherosclerotic Effects of Nicardipine and Nifedipine in Cholesterol‐Fed Rabbits

Antiatherosclerotic Effects of Nicardipine and Nifedipine in Cholesterol‐Fed Rabbits Dutch-belted rabbits fed a 2&percnt; cholesterol diet for 8 weeks developed atherosclerotic lesions that covered 37.2&percnt; ± 3.5&percnt; of the aortic luminal surface. In samples of aortic arch, accumulation of cholesterol and triglyceride was also observed. Oral administration of nicardipine or nifedipine at dosages of 40 mglkg twice daily for 8 weeks reduced plaque area by 49.2&percnt; and 58.7&percnt;, respectively. Nicardipine and nifedipine reduced cholesterol accumulation in the aortic arch by 74.5&percnt; and 69&percnt;, respectively. Triglyceride accumulation was totally abolished. Neither drug significantly altered cholesterol concentration of plasma low density lipoprotein or high density lipoprotein, although nicardipine produced a 42&percnt; reduction in cholesterol concentration of the d < 1.006 g/ml fraction. The above results suggest potential therapeutic utility of nicardipine in atherosclerosis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arteriosclerosis Wolters Kluwer Health

Antiatherosclerotic Effects of Nicardipine and Nifedipine in Cholesterol&hyphen;Fed Rabbits

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Copyright
© 1985 by American Heart Association, Inc.
ISSN
0276-5047

Abstract

Dutch-belted rabbits fed a 2&percnt; cholesterol diet for 8 weeks developed atherosclerotic lesions that covered 37.2&percnt; ± 3.5&percnt; of the aortic luminal surface. In samples of aortic arch, accumulation of cholesterol and triglyceride was also observed. Oral administration of nicardipine or nifedipine at dosages of 40 mglkg twice daily for 8 weeks reduced plaque area by 49.2&percnt; and 58.7&percnt;, respectively. Nicardipine and nifedipine reduced cholesterol accumulation in the aortic arch by 74.5&percnt; and 69&percnt;, respectively. Triglyceride accumulation was totally abolished. Neither drug significantly altered cholesterol concentration of plasma low density lipoprotein or high density lipoprotein, although nicardipine produced a 42&percnt; reduction in cholesterol concentration of the d < 1.006 g/ml fraction. The above results suggest potential therapeutic utility of nicardipine in atherosclerosis.

Journal

ArteriosclerosisWolters Kluwer Health

Published: May 1, 1985

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