Antiatherosclerotic Effects of Nicardipine and Nifedipine in Cholesterol‐Fed Rabbits
Antiatherosclerotic Effects of Nicardipine and Nifedipine in Cholesterol‐Fed Rabbits
Willis, Anthony L.; Nagel, Becky ; Churchill, Veronica ; Whyte, Mary Anne; Smith, Donald L.; Mahmud, Lshtiaq ; Puppione, Donald L.
1985-05-01 00:00:00
Dutch-belted rabbits fed a 2% cholesterol diet for 8 weeks developed atherosclerotic lesions that covered 37.2% ± 3.5% of the aortic luminal surface. In samples of aortic arch, accumulation of cholesterol and triglyceride was also observed. Oral administration of nicardipine or nifedipine at dosages of 40 mglkg twice daily for 8 weeks reduced plaque area by 49.2% and 58.7%, respectively. Nicardipine and nifedipine reduced cholesterol accumulation in the aortic arch by 74.5% and 69%, respectively. Triglyceride accumulation was totally abolished. Neither drug significantly altered cholesterol concentration of plasma low density lipoprotein or high density lipoprotein, although nicardipine produced a 42% reduction in cholesterol concentration of the d < 1.006 g/ml fraction. The above results suggest potential therapeutic utility of nicardipine in atherosclerosis.
http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.pngArteriosclerosisWolters Kluwer Healthhttp://www.deepdyve.com/lp/wolters-kluwer-health/antiatherosclerotic-effects-of-nicardipine-and-nifedipine-in-crAn2HM0Tt
Antiatherosclerotic Effects of Nicardipine and Nifedipine in Cholesterol‐Fed Rabbits
Dutch-belted rabbits fed a 2% cholesterol diet for 8 weeks developed atherosclerotic lesions that covered 37.2% ± 3.5% of the aortic luminal surface. In samples of aortic arch, accumulation of cholesterol and triglyceride was also observed. Oral administration of nicardipine or nifedipine at dosages of 40 mglkg twice daily for 8 weeks reduced plaque area by 49.2% and 58.7%, respectively. Nicardipine and nifedipine reduced cholesterol accumulation in the aortic arch by 74.5% and 69%, respectively. Triglyceride accumulation was totally abolished. Neither drug significantly altered cholesterol concentration of plasma low density lipoprotein or high density lipoprotein, although nicardipine produced a 42% reduction in cholesterol concentration of the d < 1.006 g/ml fraction. The above results suggest potential therapeutic utility of nicardipine in atherosclerosis.
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