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Androgen Receptor is Mostly Not Expressed in Gastric Cancers

Androgen Receptor is Mostly Not Expressed in Gastric Cancers LETTERS TO THE EDITOR third leading cause of cancer-related gard, a few previous studies have re- Androgen Receptor is 1,2 mortality worldwide. Epidemiologic vealed that androgen receptor (AR) is reports have indicated that regardless expressed in a subset of GC tissues Mostly Not Expressed in of etiologies, the incidence of GC is with still conflicting its prognostic 3–5 Gastric Cancers higher in males than in females with a role. If androgen signaling axis plays 1,2 male-to-female ratio of B2:1. Many an important role in GC, it may en- To the Editor: investigators have believed that this hance our understanding for gastric Gastric cancer (GC) represents disparity suggests a possible role of carcinogenesis and also broaden the the fifth most common cancer and the androgen signaling in GC. In this re- therapeutic options. FIGURE 1. AR expression in GC cells and tissues. A, Immunohistochemistry for AR reveals that AR is not expressed in normal gastric epithelium and GC tissues, whereas diffuse, strong nuclear AR staining was noted in prostate cancer (bar = 50 mm). B, Protein expression level of AR in various GC cell lines detected by Western blotting. Prostate cancer cell lines were used positive (LNCap) and negative controls http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Androgen Receptor is Mostly Not Expressed in Gastric Cancers

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Publisher
Wolters Kluwer Health
Copyright
Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
1541-2016
eISSN
1533-4058
DOI
10.1097/PAI.0000000000000559
Publisher site
See Article on Publisher Site

Abstract

LETTERS TO THE EDITOR third leading cause of cancer-related gard, a few previous studies have re- Androgen Receptor is 1,2 mortality worldwide. Epidemiologic vealed that androgen receptor (AR) is reports have indicated that regardless expressed in a subset of GC tissues Mostly Not Expressed in of etiologies, the incidence of GC is with still conflicting its prognostic 3–5 Gastric Cancers higher in males than in females with a role. If androgen signaling axis plays 1,2 male-to-female ratio of B2:1. Many an important role in GC, it may en- To the Editor: investigators have believed that this hance our understanding for gastric Gastric cancer (GC) represents disparity suggests a possible role of carcinogenesis and also broaden the the fifth most common cancer and the androgen signaling in GC. In this re- therapeutic options. FIGURE 1. AR expression in GC cells and tissues. A, Immunohistochemistry for AR reveals that AR is not expressed in normal gastric epithelium and GC tissues, whereas diffuse, strong nuclear AR staining was noted in prostate cancer (bar = 50 mm). B, Protein expression level of AR in various GC cell lines detected by Western blotting. Prostate cancer cell lines were used positive (LNCap) and negative controls

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Feb 1, 2020

References

  • Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012
  • Model-based patterns in stomach cancer mortality worldwide
  • Androgen receptor (AR) expression is an independent unfavorable prognostic factor in gastric cancer
  • Expression profile and prognostic role of sex hormone receptors in gastric cancer
  • Androgen receptor promotes gastric cancer cell migration and invasion via AKT-phosphorylation dependent upregulation of matrix metalloproteinase 9
  • Analytic validation of RNA in situ hybridization (RISH) for AR and AR-V7 expression in human prostate cancer
  • Sex hormone receptors in gastric cancer