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RESEARCH ARTICLE Androgen Receptor Expression in Vascular Neoplasms of the Breast Richa Jain, MD, Pincas Bitterman, MD, Ihab Lamzabi, MD, Vijaya B. Reddy, MD, and Paolo Gattuso, MD (Appl Immunohistochem Mol Morphol 2014;22:132–135) Introduction: Androgen receptors (AR) have been reported to be present in normal breast tissue and breast carcinomas. The following study was undertaken to assess the expression of AR ndrogen receptors (AR) have been reported to be in vascular neoplasms of the breast. Apresent in 70% to 90% of breast carcinomas and Materials and Methods: All patients with histologically diag- normal breast tissue in both men and women. AR ex- nosed hemangioma, angiolipoma, atypical vascular pro- pression has been correlated to smaller tumor size, lower liferation, and angiosarcoma of the breast were retrieved from histologic grade, and hormone receptor-positive and non– the clinical and pathology database at Rush University Medical triple-negative breast cancer and correlates with favorable 1–4 Center. The slides stained with hematoxylin and eosin were re- differentiation. However, there is no literature regarding viewed and immunohistochemical staining for AR (Dako; clone the expression of AR in vascular breast neoplasms. The AR441) was performed on paraffin-embedded tissue. Any following study was undertaken to assess the expression
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Feb 1, 2014
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