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Androgen Receptor Expression in Gastrointestinal Stromal Tumor

Androgen Receptor Expression in Gastrointestinal Stromal Tumor TECHNICAL ARTICLE Androgen Receptor Expression in Gastrointestinal Stromal Tumor Lisandro F. Lopes, MD, PhD and Carlos E. Bacchi, MD, PhD 5–7 carcinomas, respectively. The expression of hormone Abstract: The aim of this study was to evaluate the expression of receptors and the potential utility of antihormonal estrogen, progesterone, and androgen receptors in a large series therapy in some mesenchymal tumors are described in of gastrointestinal stromal tumors. Clinical and pathologic data the literature, with some responses in cases of desmoid were reviewed in 427 cases of gastrointestinal stromal tumor and tumors, leiomyosarcomas, endometrial stromal neo- 8–14 the expression of such hormone receptors was investigated by plasms, and osteosarcomas. immunohistochemistry using tissue microarray technique. All However, little is known about the status of 15–17 tumors were negative for estrogen receptor expression. Proges- hormonal receptors in GIST. Few previous studies terone and androgen receptors expression was observed in 5.4% in a limited number of cases have showed that GISTs are and 17.6% of tumors, respectively. We found the higher average negative for ER and progesterone receptor (PR), with the age at diagnosis, the lower frequency of tumors located in the exception of only 1 case occurring during pregnancy, small intestine, and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Androgen Receptor Expression in Gastrointestinal Stromal Tumor

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ISSN
1541-2016
DOI
10.1097/PAI.0b013e31818fcfde
pmid
19077908
Publisher site
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Abstract

TECHNICAL ARTICLE Androgen Receptor Expression in Gastrointestinal Stromal Tumor Lisandro F. Lopes, MD, PhD and Carlos E. Bacchi, MD, PhD 5–7 carcinomas, respectively. The expression of hormone Abstract: The aim of this study was to evaluate the expression of receptors and the potential utility of antihormonal estrogen, progesterone, and androgen receptors in a large series therapy in some mesenchymal tumors are described in of gastrointestinal stromal tumors. Clinical and pathologic data the literature, with some responses in cases of desmoid were reviewed in 427 cases of gastrointestinal stromal tumor and tumors, leiomyosarcomas, endometrial stromal neo- 8–14 the expression of such hormone receptors was investigated by plasms, and osteosarcomas. immunohistochemistry using tissue microarray technique. All However, little is known about the status of 15–17 tumors were negative for estrogen receptor expression. Proges- hormonal receptors in GIST. Few previous studies terone and androgen receptors expression was observed in 5.4% in a limited number of cases have showed that GISTs are and 17.6% of tumors, respectively. We found the higher average negative for ER and progesterone receptor (PR), with the age at diagnosis, the lower frequency of tumors located in the exception of only 1 case occurring during pregnancy, small intestine, and

Journal

Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health

Published: Mar 1, 2009

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