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Analysis of Major Known Driver Mutations and Prognosis in Resected Adenosquamous Lung Carcinomas

Analysis of Major Known Driver Mutations and Prognosis in Resected Adenosquamous Lung Carcinomas ORIGINAL ARTICLE Analysis of Major Known Driver Mutations and Prognosis in  Resected Adenosquamous Lung Carcinomas Rui Wang, MD,*† Yunjian Pan, MD,*† Chenguang Li, MD,PhD,*† Huibiao Zhang, MD,‡ David Garfield, MD,§ Yuan Li, MD, †║ Ting Ye, MD,*† Haichuan Hu, MD,*† Xiaoyang Luo, MD,*† Hang Li, MD,*† Yang Zhang, MD,*† Jie Zhang, MD,*† Xiaoyan Zhou, MD,†║ Lei Shen, MD,†║ William Pao, MD,PhD,¶ Yihua Sun, MD,*† and Haiquan Chen, MD*† ung cancer is the most common cause of cancer-related death Introduction: Genotyping for driver mutations is now routinely used Lworldwide. Adenosquamous lung carcinoma (AdSqLC) is to guide clinical care of patients with lung cancer. Adenosquamous a subtype of non–small-cell lung cancer (NSCLC), account- lung carcinoma (AdSqLC) is a subtype of cancer that contains both 2–4 ing for 1.6% to 4.5% of lung cancers. According to World adenocarcinoma and squamous cell carcinoma. However, the inci- Health Organization classification, AdSqLC is defined as a dence, clinicopathologic characteristics, and prognostic implications carcinoma showing components of both adenocarcinoma and of major driver mutations in AdSqLCs are not well established. squamous cell carcinoma, with each component comprising Methods: Seventy-six resected AdSqLCs and 646 lung adenocarci- at least 10% of the tumor. AdSqLCs have more aggressive nomas were screened for known genetic alterations involving EGFR, behavior and worse http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Thoracic Oncology Wolters Kluwer Health

Analysis of Major Known Driver Mutations and Prognosis in Resected Adenosquamous Lung Carcinomas

Chen, Haiquan
Journal of Thoracic Oncology , Volume 9 (6) – Jun 1, 2014
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Copyright
Copyright © 2013 by the International Association for the Study of Lung Cancer
ISSN
1556-0864
DOI
10.1097/JTO.0b013e3182a406d1
pmid
24481316
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Analysis of Major Known Driver Mutations and Prognosis in  Resected Adenosquamous Lung Carcinomas Rui Wang, MD,*† Yunjian Pan, MD,*† Chenguang Li, MD,PhD,*† Huibiao Zhang, MD,‡ David Garfield, MD,§ Yuan Li, MD, †║ Ting Ye, MD,*† Haichuan Hu, MD,*† Xiaoyang Luo, MD,*† Hang Li, MD,*† Yang Zhang, MD,*† Jie Zhang, MD,*† Xiaoyan Zhou, MD,†║ Lei Shen, MD,†║ William Pao, MD,PhD,¶ Yihua Sun, MD,*† and Haiquan Chen, MD*† ung cancer is the most common cause of cancer-related death Introduction: Genotyping for driver mutations is now routinely used Lworldwide. Adenosquamous lung carcinoma (AdSqLC) is to guide clinical care of patients with lung cancer. Adenosquamous a subtype of non–small-cell lung cancer (NSCLC), account- lung carcinoma (AdSqLC) is a subtype of cancer that contains both 2–4 ing for 1.6% to 4.5% of lung cancers. According to World adenocarcinoma and squamous cell carcinoma. However, the inci- Health Organization classification, AdSqLC is defined as a dence, clinicopathologic characteristics, and prognostic implications carcinoma showing components of both adenocarcinoma and of major driver mutations in AdSqLCs are not well established. squamous cell carcinoma, with each component comprising Methods: Seventy-six resected AdSqLCs and 646 lung adenocarci- at least 10% of the tumor. AdSqLCs have more aggressive nomas were screened for known genetic alterations involving EGFR, behavior and worse

Journal

Journal of Thoracic Oncology – Wolters Kluwer Health

Published: Jun 1, 2014

References

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    Parkin
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    Filosso
  • Clinicopathological characteristics of resected adenosquamous cell carcinoma of the lung: risk of coexistent double cancer
    Uramoto
  • Prognosis and survival after radical resection of primary adenosquamous lung carcinoma
    Gawrychowski