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REVIEW URRENT An open-ended plea for the development of a PINION global database of HIV vaccine responses a a b a Peter Wilkinson , Abdelali Filali-Mouhim , Shuzhao Li , Jeffrey Ahlers , a b a John Schatzle , Bali Pulendran , Rafick-Pierre Sekaly , and Mark J. Cameron Purpose of review The purpose of this review is to describe a critical need of the HIV research community for a globally accessible database of HIV vaccine responses that stores data from multiple assay platforms in the form of lists of correlates of immune protection and vaccine efficacy. This is not a detailed review but a first step toward developing a dialogue among investigators and funding organizations to build upon existing resources to efficiently develop a HIV vaccine response and correlates database. We also discuss examples of databases that complement our needs and could be integrated into our proposed database requirements. Recent findings Several vaccine-related databases that store information at the study level currently exist, however, at the present time, a correlates of immune protection database does not exist. Summary Here, we discuss the scientific climate surrounding HIV vaccine development with the evolution of systems biology approaches, the problems at
Current Opinion in HIV and Aids – Wolters Kluwer Health
Published: Jan 1, 2012
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