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Altered Splicing of JARID1B in Development of Human Cutaneous Melanoma?

Altered Splicing of JARID1B in Development of Human Cutaneous Melanoma? RESEARCH ARTICLE Altered Splicing of JARID1B in Development of Human Cutaneous Melanoma? Łukasz Kuz´bicki, PhD,* Dariusz Lange, MD, PhD,w Anita Stracz ˛ yn´ska-Niemiec, MD, PhD,w and Barbara W. Chwirot, PhD* ID1B is of a crucial importance for continuous growth of 10,11 Abstract: Upregulated expression of histone H3K4 demethylase melanoma. The authors found that the subpopulation JARID1B has been found in several types of human cancer, but of the melanoma cells expressing JARID1B cycled much the expression pattern of this protein in benign naevi and human slower than the main population of the tumor cells and cutaneous melanomas seems to differ from that described for thus might be more resistant to various antitumor drugs. other tumors. We demonstrate that the apparent contradiction A more recent study of the same group demonstrated that may be because of the fact that the malignant transformation of the intrinsic multidrug resistance of the slowly cycling melanocytes is associated not so much with a general enhance- melanoma cells expressing high levels of JARID1B could ment of a total expression of JARID1B but rather with a change be significantly reduced by treatment with inhibitors of in relative expression levels of individual splicing variants of the mitochondrial http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Altered Splicing of JARID1B in Development of Human Cutaneous Melanoma?

Applied Immunohistochemistry & Molecular Morphology , Volume Publish Ahead of Print – Mar 1, 2015

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Copyright
Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
1541-2016
DOI
10.1097/PAI.0000000000000170
pmid
25789538
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Altered Splicing of JARID1B in Development of Human Cutaneous Melanoma? Łukasz Kuz´bicki, PhD,* Dariusz Lange, MD, PhD,w Anita Stracz ˛ yn´ska-Niemiec, MD, PhD,w and Barbara W. Chwirot, PhD* ID1B is of a crucial importance for continuous growth of 10,11 Abstract: Upregulated expression of histone H3K4 demethylase melanoma. The authors found that the subpopulation JARID1B has been found in several types of human cancer, but of the melanoma cells expressing JARID1B cycled much the expression pattern of this protein in benign naevi and human slower than the main population of the tumor cells and cutaneous melanomas seems to differ from that described for thus might be more resistant to various antitumor drugs. other tumors. We demonstrate that the apparent contradiction A more recent study of the same group demonstrated that may be because of the fact that the malignant transformation of the intrinsic multidrug resistance of the slowly cycling melanocytes is associated not so much with a general enhance- melanoma cells expressing high levels of JARID1B could ment of a total expression of JARID1B but rather with a change be significantly reduced by treatment with inhibitors of in relative expression levels of individual splicing variants of the mitochondrial

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Mar 1, 2015

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