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Alpha-methylacyl-CoA Racemase/P504S Overexpression in Colorectal Carcinoma is Correlated With Tumor Differentiation

Alpha-methylacyl-CoA Racemase/P504S Overexpression in Colorectal Carcinoma is Correlated With... RESEARCH ARTICLE Alpha-methylacyl-CoA Racemase/P504S Overexpression in Colorectal Carcinoma is Correlated With Tumor Differentiation Xueying Shi, MD, PhD, Encong Gong, MD, and Xiaopan Wu, BS lpha-methylacyl-CoA racemase (AMACR), which is Abstract: Alpha-methylacyl-CoA racemase (AMACR)/P504S is Aalso known as P504S, is a well-characterized enzyme, an enzyme involved in the metabolism of branched-chain fatty which plays an important role in bile acid biosynthesis acids. Little is known about correlation of AMACR expression and b-oxidation of branched-chain fatty acids. It cata- with colorectal carcinoma (CRC) differentiation and prognosis. lyzes the conversion of several (2R)-methyl-branched- We investigated the expression of AMACR in 106 cases of chain fatty acyl-CoAs to their (S)-stereoisomers in primary CRC, and in 47 lymph nodes with metastatic CRC by mitochondria and peroxisomes. Under normal condi- immunohistochemical analysis. These cases were divided into 3 tions, AMACR is transported to both the peroxisomal groups according to the histologic differentiation of the primary and mitochondrial compartments and is detectable in a tumors. group A included 50 cases of histologically well and variety of tissues, including liver, kidney, skeletal muscle, 1–4 moderately differentiated CRCs, 20 of these with lymph node gallbladder, and brain. Epidemiologic studies have metastasis; group B included 23 cases of well http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Immunohistochemistry & Molecular Morphology Wolters Kluwer Health

Alpha-methylacyl-CoA Racemase/P504S Overexpression in Colorectal Carcinoma is Correlated With Tumor Differentiation

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/lp/wolters-kluwer-health/alpha-methylacyl-coa-racemase-sol-p504s-overexpression-in-colorectal-ZS76k0Xo9k
ISSN
1541-2016
DOI
10.1097/01.pai.0000213107.20355.d8
pmid
17525630
Publisher site
See Article on Publisher Site

Abstract

RESEARCH ARTICLE Alpha-methylacyl-CoA Racemase/P504S Overexpression in Colorectal Carcinoma is Correlated With Tumor Differentiation Xueying Shi, MD, PhD, Encong Gong, MD, and Xiaopan Wu, BS lpha-methylacyl-CoA racemase (AMACR), which is Abstract: Alpha-methylacyl-CoA racemase (AMACR)/P504S is Aalso known as P504S, is a well-characterized enzyme, an enzyme involved in the metabolism of branched-chain fatty which plays an important role in bile acid biosynthesis acids. Little is known about correlation of AMACR expression and b-oxidation of branched-chain fatty acids. It cata- with colorectal carcinoma (CRC) differentiation and prognosis. lyzes the conversion of several (2R)-methyl-branched- We investigated the expression of AMACR in 106 cases of chain fatty acyl-CoAs to their (S)-stereoisomers in primary CRC, and in 47 lymph nodes with metastatic CRC by mitochondria and peroxisomes. Under normal condi- immunohistochemical analysis. These cases were divided into 3 tions, AMACR is transported to both the peroxisomal groups according to the histologic differentiation of the primary and mitochondrial compartments and is detectable in a tumors. group A included 50 cases of histologically well and variety of tissues, including liver, kidney, skeletal muscle, 1–4 moderately differentiated CRCs, 20 of these with lymph node gallbladder, and brain. Epidemiologic studies have metastasis; group B included 23 cases of well

Journal

Applied Immunohistochemistry & Molecular MorphologyWolters Kluwer Health

Published: Jun 1, 2007

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