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C. Heyningen (2005)
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This paper provides interesting evidence on the tolerogenic role of Kupffer cells in the liver
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This paper reviews the location of the metabolic activation of drugs and its relevance to drug hypersensitivity, with reference to the liver
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Excellent review of immunology of the liver, with a description of the different cell types and their role in surveillance and activation mechanisms
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This is an interesting paper examining how the metabolism and bioactivation of drugs may be relevant in understanding idiosynchratic liver damage induced by drugs
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Relevant paper illustrating the experience gained with previous compounds involving the mechanisms of organ-specific idiosynchratic drug toxicity
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An excellent paper covering the various aspects of drug metabolism, bioactivation and adduct formation of drugs, with a well defined focus on the liver
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a,b c Jose ´ V. Castell and Marta Castell Purpose of review Introduction To examine recent advances in our understanding of how Drug-induced allergic hepatitis is a liver-specific inflam- drugs can trigger a hypersensitivity reaction in the liver, how matory reaction caused by hypersensitivity to a particular tolerance is lost, the mechanisms of damage to hepatocytes drug. Although less common than other forms of drug- and the strategies towards a better assessment of an induced hepatotoxicity, it has more serious clinical idiosyncratic drug liver reaction. implications, the outcome can sometimes be fatal, and Recent findings it appears to increase in proportion to the number of Formation and presentation of drug – protein adducts, or a prescribed drugs. There is convincing experimental evi- direct interaction with the major histocompatibility complex/ dence to implicate the immune system in the pathogen- T-cell receptor complex is a necessary but not sufficient esis of many drug hypersensitivity reactions. The onset of stimulus to trigger a hypersensitivity reaction. Liver shows a hypersensitivity reaction frequently involves covalent considerable tolerogenic potential towards drug adducts. binding of the drug to proteins (generally as a result of its Recent studies highlight allergic hepatitis as a loss of liver metabolism
Current Opinion in Allergy and Clinical Immunology – Wolters Kluwer Health
Published: Aug 1, 2006
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