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Allergic hepatitis induced by drugs

Allergic hepatitis induced by drugs a,b c Jose ´ V. Castell and Marta Castell Purpose of review Introduction To examine recent advances in our understanding of how Drug-induced allergic hepatitis is a liver-specific inflam- drugs can trigger a hypersensitivity reaction in the liver, how matory reaction caused by hypersensitivity to a particular tolerance is lost, the mechanisms of damage to hepatocytes drug. Although less common than other forms of drug- and the strategies towards a better assessment of an induced hepatotoxicity, it has more serious clinical idiosyncratic drug liver reaction. implications, the outcome can sometimes be fatal, and Recent findings it appears to increase in proportion to the number of Formation and presentation of drug – protein adducts, or a prescribed drugs. There is convincing experimental evi- direct interaction with the major histocompatibility complex/ dence to implicate the immune system in the pathogen- T-cell receptor complex is a necessary but not sufficient esis of many drug hypersensitivity reactions. The onset of stimulus to trigger a hypersensitivity reaction. Liver shows a hypersensitivity reaction frequently involves covalent considerable tolerogenic potential towards drug adducts. binding of the drug to proteins (generally as a result of its Recent studies highlight allergic hepatitis as a loss of liver metabolism http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Allergy and Clinical Immunology Wolters Kluwer Health

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References (67)

ISSN
1528-4050
eISSN
1473-6322
DOI
10.1097/01.all.0000235898.80052.80
pmid
16825865
Publisher site
See Article on Publisher Site

Abstract

a,b c Jose ´ V. Castell and Marta Castell Purpose of review Introduction To examine recent advances in our understanding of how Drug-induced allergic hepatitis is a liver-specific inflam- drugs can trigger a hypersensitivity reaction in the liver, how matory reaction caused by hypersensitivity to a particular tolerance is lost, the mechanisms of damage to hepatocytes drug. Although less common than other forms of drug- and the strategies towards a better assessment of an induced hepatotoxicity, it has more serious clinical idiosyncratic drug liver reaction. implications, the outcome can sometimes be fatal, and Recent findings it appears to increase in proportion to the number of Formation and presentation of drug – protein adducts, or a prescribed drugs. There is convincing experimental evi- direct interaction with the major histocompatibility complex/ dence to implicate the immune system in the pathogen- T-cell receptor complex is a necessary but not sufficient esis of many drug hypersensitivity reactions. The onset of stimulus to trigger a hypersensitivity reaction. Liver shows a hypersensitivity reaction frequently involves covalent considerable tolerogenic potential towards drug adducts. binding of the drug to proteins (generally as a result of its Recent studies highlight allergic hepatitis as a loss of liver metabolism

Journal

Current Opinion in Allergy and Clinical ImmunologyWolters Kluwer Health

Published: Aug 1, 2006

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