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CASE REPORT ALK-positive Diffuse Large B-cell Lymphoma With the t(2;17)(p23;q23) Da Zhang, MD, PhD,* Ryan C. Denley, BS,*w Daniel A. Filippa, MD,* and Julie Teruya-Feldstein, MD* with plasmablastic and anaplastic morphologic features, Abstract: Diffuse large B-cell lymphoma (DLBCL) with first recognized in 1997 shows characteristic ALK plasmablastic features associated with t(2;17)(p23;q23) and protein expression. Subsequently, cases were shown to characteristic granular cytoplasmic anaplastic lymphoma ki- be associated with more commonly t(2;17)(p23;q23), nase-1 (ALK1) protein expression is a rare lymphoma subtype. rarely with t(2;5)(p23;q35), and recently a cryptic inser- Nodal and extranodal involvement has been reported. Our case tion of the ALK gene into chromosome 4 at band 4q22- is a 32-year-old man with right cervical adenopathy. Lymph 24. This rare lymphoma subtype has been described in 4–8 node biopsy showed large atypical cells with prominent nodal and extranodal sites. A recent detailed clinico- plasmablastic differentiation, abundant amphophilic cytoplasm, pathologic review of the literature has been reported with and prominent central nucleoli. Paraffin immunohistochemistry most patients being male with pediatric cases identified. showed finely granular cytoplasmic ALK1 expression, positive Immunophenotypically, tumor cells have been reported CD138, IgA, p63 (VS38), focal positive epithelial membrane as most commonly positive for CD138/VS38, ALK,
Applied Immunohistochemistry & Molecular Morphology – Wolters Kluwer Health
Published: Mar 1, 2009
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